Articles with the keyword: 


Insulin Resistance, Diabetes Increase Liver Fibrosis in Patients With Genotype 1 HCV
kavin submitted, created time 6 months 1 week (www.medscape.com)
NEW YORK (Reuters Health) Jun 25 - Insulin resistance is a major determinant of advanced hepatic fibrosis in patients with chronic hepatitis C resulting from genotype 1 (G1-HCV), especially in the presence of severe necroinflammation, according to study findings published in the May issue of the American Journal of Gastroenterology.
"Metabolic factors may affect the course of chronic hepatitis C," Dr. Salvatore Petta, of the University of Palermo, Italy, and colleagues write 


Influence of gestational diabetes on the long-term control of glucose tolerance
yangjane submitted, created time 1 year 1 month (www.springerlink.com)
Even in women who maintain normal insulin sensitivity, impaired beta cell function is carried over into the NGT status several years after a GDM pregnancy. 


Silencing Insulin Resistance through SIRT1
davidd submitted, created time 1 year 2 months (www.cellmetabolism.org)
Insulin resistance is an important risk factor for the development of type 2 diabetes and the metabolic syndrome. A new study in this issue of Cell Metabolism (Sun et al., 2007) shows that SIRT1, a mammalian sirtuin homolog and histone deacetylase, can ameliorate insulin resistance by silencing expression of protein tyrosine phosphatase 1B, a major negative regulator of insulin action. 


New blood test might offer early warning of deep belly fat
bianjie submitted, created time 1 year 5 months (www.eurekalert.org)
Measuring levels of a chemical found in blood offers the best indicator yet of the amount of fat surrounding abdominal organs, according to a new study of lean and obese individuals reported in the July issue of Cell Metabolism, a publication of Cell Press. The buildup of such "visceral fat" is of particular health concern as it has been linked to insulin resistance, type 2 diabetes, and heart disease risk. 


Retinaldehyde represses adipogenesis and diet-induced obesity
addict submitted, created time 1 year 7 months (www.nature.com)
"Here we show that Rald is present in rodent fat, binds retinol-binding proteins (CRBP1, RBP4), inhibits adipogenesis and suppresses peroxisome proliferator-activated receptor-gamma and RXR responses. In vivo, mice lacking the Rald-catabolizing enzyme retinaldehyde dehydrogenase 1 (Raldh1) resisted diet-induced obesity and insulin resistance and showed increased energy dissipation. In ob/ob mice, administrating Rald or a Raldh inhibitor reduced fat and increased insulin sensitivity 


medal submitted, created time 1 year 7 months (hyper.ahajournals.org)
"Insulin resistance syndrome has been observed in women with hypertensive disease of pregnancy, but few studies evaluated the presence of the syndrome a few years after delivery. The objective of this study was to evaluate the presence of insulin resistance and its metabolic alterations in these women compared with those who had a normal pregnancy." 


Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease
athena submitted, created time 1 year 8 months (diabetes.diabetesjournals.org)
"Recent evidence points to molecules secreted by the adipose tissue, or adipokines, as possible links between increased adipose mass and metabolic abnormalities. Among these molecules, adiponectin has drawn much attention because of its insulin-sensitizing and antiatherogenic actions, suggesting that genetic deficits in its production or action may contribute to insulin resistance and coronary artery disease (CAD). " 


The 2005 Dietary Guidelines for Americans and Insulin Resistance in the Framingham Offspring Cohort
alpha submitted, created time 1 year 8 months (care.diabetesjournals.org)
"Consumption of a diet consistent with the 2005 DGA may be an effective means to limit insulin resistance in women. " 


Effects of Palmitate on Ca2+ Handling in Adult Control and ob/ob Cardiomyocytes
athena submitted, created time 1 year 8 months (diabetes.diabetesjournals.org)
"Increased saturated fatty acid levels impair cellular Ca2+ handling and contraction in a ROS-dependent manner in normal cardiomyocytes. Conversely, high fatty acid levels may be vital to sustain cardiac Ca2+ handling and contraction in obesity and insulin-resistant conditions. " 


Evolutionary origins of Insulin Resistance: A behavioral switch hypothesis
cappuccion submitted, created time 1 year 8 months (www.biomedcentral.com)
Insulin resistance, which can lead to a number of diseases including type 2 diabetes and coronary heart disease, is believed to have evolved as an adaptation to periodic starvation. The thrifty gene and thrifty phenotype hypotheses constitute the dominant paradigm for over four decades. With an increasing understanding of the diverse effects of impairment of the insulin signaling pathway, the existing hypotheses are proving inadequate. Through the research, they find Gestational insulin resistance diverts more energy through the placenta, resulting in increased investment per offspring 


gp130 receptor ligands as potential therapeutic targets for obesity
medal submitted, created time 1 year 8 months (www.jci.org)
"Obesity and its related cluster of pathophysiologic conditions including insulin resistance, glucose intolerance, dyslipidemia, and hypertension are recognized as growing threats to world health. It is now estimated that 10% of the world’s population is overweight or obese. As a result, new therapeutic options for the treatment of obesity are clearly warranted." 


athena submitted, created time 1 year 9 months (www.ajcn.org)
Short-term soy-nut consumption improved glycemic control and lipid profiles in postmenopausal women with the metabolic syndrome. 


crackpot submitted, created time 1 year 9 months (mcb.asm.org)
“Interleukin 6 (IL-6) is an independent predictor of type 2 diabetes and cardiovascular disease and is correlated with insulin resistance.……IL-6 treatment reduced insulin-stimulated phosphorylation of eNOS at the stimulatory Ser1177 site and impaired insulin-stimulated eNOS dephosphorylation at the inhibitory Thr495 site. Insulin-stimulated eNOS activation and NO production were also inhibited by IL-6; these effects were reversed by inhibition of JNK and ERK1/2 


Visfatin is down-regulated by overfeeding
amanda submitted, created time 1 year 10 months (www.ajcn.org)
Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men.Under physiologic conditions, visfatin does not appear to control glucose metabolism but may play a regulatory role in lipid metabolism. 
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