Zinc is a novel intracellular second messenger

crackpot submitted, created time 1 year 7 months (www.jcb.org)

"Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated. Although zinc affects several signaling molecules and may act as a neurotransmitter, it remains unknown whether zinc acts as an intracellular second messenger capable of transducing extracellular stimuli into intracellular signaling events

Submit comment | Blog It | Email It | Keywords: BMMC DTPA, diethylenetriaminepentaacetic acid ERK extracellular signal-regulated kinase Fc{varepsilon}RI Fc{varepsilon} receptor I interleukin IP3R MEK, MAPK&ERK kinase TIRF

Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-{gamma} production and the induction of Th1 cell differentiation

dovechocolate submitted, created time 1 year 9 months (bloodjournal.hematologylibrary.org)

It is well documented that dendritic cells (DCs), representative antigen-presenting cells, are important sources of Th1-promoting cytokines and are actively involved in the regulation of T helper cell differentiation. However, the intracellular event that regulates this process is still largely unknown. In this study, we examined the role of Tyk2, a JAK kinase that is involved in the signaling pathway under IL-12 and IL-23, in DC functions

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Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin

athena submitted, created time 1 year 9 months (diabetes.diabetesjournals.org)

We generated preadipocyte cell lines impaired in adrenomedullin production through integration of an adrenomedullin small interfering RNA expression vector. The reduction of adrenomedullin synthesis strongly accelerated adipose differentiation.

Submit comment | Blog It | Email It | Keywords: interleukin insulin responsive element peroxisome proliferator–activated recept