[FW]FDA Approves Kidney Cancer Drug

DanyC submitted, created time 1 year 7 months (www.foxnews.com)

Torisel, which contains the active ingredient temsirolimus, was approved based on a study that showed the drug prolonged survival of patients with renal cell carcinoma. The drug is an enzyme inhibitor, a protein that regulates cell production, cell growth and cell survival.

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Moderate drinking may lower kidney cancer risk

Rhett submitted, created time 1 year 7 months (www.sciam.com)

Having a drink or two per day appears to modestly decrease the risk of developing kidney cell cancer, new research findings suggest, regardless of the type of alcoholic drink that is consumed. Multiple studies have hinted at an inverse association between alcohol and kidney cancer, investigators point out in the Journal of the National Cancer Institute. "But previous studies were inconclusive, and it is not clear whether alcohol itself affects risk, or if the effects are due to specific types of beverages," lead author Dr. Jung Eun Lee told Reuters Health.

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Never escape :Childhood cancer survivors still at higher risk of cancer .

Reviver submitted, created time 1 year 10 months (www.sciam.com)

By studying the files of 14,372 participants of the Childhood Cancer Survivor Study. scientists identified 108 patients with cancer of the connective tissue, also known as sarcoma, that was diagnosed an average of 11 years after their original cancer diagnosis. Their risk of sarcoma was more than nine-fold higher than individuals in the general population.

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Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cell

Scarlett submitted, created time 1 year 10 months (www.molecular-cancer.com)

PTEN, a tumor suppressor gene, was frequently mutated or deleted in a wide variety of solid tumors, and these cancers are generally more aggressive and difficult to treat than those possessing wild type PTEN. While PTEN lies upstream of the phosphoinositide-3 kinase signaling pathway, the mechanisms that mediate its effects on tumor survival remain incompletely understood. Renal cell carcinoma (RCC) is associated with frequent treatment failures (~90% in metastatic cases), and these tumors frequently contain PTEN abnormalities

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