Singapore to examine kidney trading

sea-maid submitted, created time 4 months 21 hours (news.yahoo.com)

Singapore is considering legalizing kidney trading to help meet demand for kidney transplants, the city-state's health minister said Monday

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Development of end stage renal disease following an acute cardiac event

sea-maid submitted, created time 5 months 1 day (www.nature.com)

The author determined the rate and risk factors for end-stage renal disease (ESRD) in consecutive patients discharged after a cardiac event in a large, unbiased Canadian cohort that receives universal health coverage.

1 comment | Blog It | Email It | Keywords: kidneys risk factors kidney disease cardiac arrest cardiac events renal disease

RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease

jerry submitted, created time 5 months 1 week (diabetes.diabetesjournals.org)

This article tells us that high glucose activates RhoA/Rho-kinase in MCs, leading to downstream AP-1 activation and fibronectin induction. Inhibition of this pathway in vivo prevents the pathologic changes of diabetic nephropathy, supporting a potential role for inhibitors of RhoA/Rho in the treatment of diabetic renal disease.

4 comments | Blog It | Email It | Keywords: renal disease AP-1 kidneys diabetes RhoA Rho diabetic renal disease Rho kinase

New Combo Treatment Extends Kidney Cancer Survival

asuser submitted, created time 11 months 10 hours (health.allrefer.com)

A combination treatment with two drugs, Avastin (bevacizumab) plus interferon, extends the life of patients with kidney cancer, European researchers report.

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CD4(+) T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25(+) T cells

Immunology submitted, created time 11 months 3 weeks (www.ncbi.nlm.nih.gov)

BACKGROUND: The human 5T4 (h5T4) oncofoetal antigen is expressed by a wide variety of human carcinomas including colorectal, ovarian, gastric and renal, but rarely on normal tissues. Its restricted expression on tumour tissues as well as its association with tumour progression and bad prognosis has driven the development of a MVA-based vaccine (TroVax) which has been tested in several early phase clinical trials and these studies have led to the start of a phase III trial in renal cell carcinoma patients

Submit comment | Blog It | Email It | Keywords: kidneys RCC T-cells immunology cancer 5T4 T regulatory cells human renal cell carcinoma human renal cell carcinoma (RCC) CD4+ T cells

Insomnia may lead to toilet visits

merry submitted, created time 1 year 3 months (www.reutershealth.com)

Tests on 20 people who were deliberately deprived of sleep produced more urine at night, and it was saltier than usual, the researchers said. The effects were much stronger in men than in women.

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