Articles with the keyword:
5

Modelling of the ABL and ARG proteins predicts two functionally critical regions that are natively unfolded.

mset33 submitted, created time 1 year 6 months (www.ncbi.nlm.nih.gov)

The ABL and ARG tyrosine kinases regulate many pivotal cellular processes and are implicated in the pathogenesis of several forms of leukemia. We have modelled the previously uncharacterized core domain (SH3-SH2-tyrosine kinase) and C-terminal actin-binding domain of ARG. We have also investigated the structural arrangement of the ABL and ARG Cap region and of the long multifunctional region located downstream of the tyrosine kinase domain

5

Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)

dovechocolate submitted, created time 1 year 9 months (bloodjournal.hematologylibrary.org)

Acquired imatinib resistance in advanced Philadelphia positive acute lymphoblastic leukemia (Ph+ALL) has been associated with mutations in the kinase domain (KD) of BCR-ABL. We examined the prevalence of KD mutations in newly diagnosed and imatinib naive Ph+ALL patients and assessed their clinical relevance in the setting of uniform front-line therapy. with imatinib in combination with chemotherapy

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