Articles with the keyword: 
Doctors say marrow transplant may have cured AIDS
sea-maid submitted, created time 1 day 3 hours (health.yahoo.com)
An American man who suffered from AIDS appears to have been cured of the disease twenty months after receiving a targeted bone marrow transplant normally used to fight leukemia, his doctors said.
While researchers--and the doctors themselves--caution that the case might be no more than a fluke, others say it may inspire a greater interest in gene therapy to fight the disease that claims 2 million lives each year. The virus has infected 33 million people worldwide.
Dr 
Bone marrow transplant suppresses AIDS in patient
sea-maid submitted, created time 1 week 2 days (www.reuters.com)
A bone marrow transplant using stem cells from a donor with natural genetic resistance to the AIDS virus has left an HIV patient free of infection for nearly two years, German researchers.
The patient, an American living in Berlin, was infected with the human immunodeficiency virus that causes AIDS and also had leukemia. The best treatment for the leukemia was a bone marrow transplant, which takes the stem cells from a healthy donor's immune system to replace the patient's cancer-ridden cells.
Dr
Blocking enzyme could help in rare blood cancer
jerry submitted, created time 2 months 3 days (www.reuters.com)
An enzyme that fights some kinds of cancers may foster the growth of a rare type of leukemia that affects babies, U.S. researchers said on Wednesday in a finding that may lead to new drugs for the hard-to-treat disease. There is also talk of applications in Alzheimer's and diabetes.
The enzyme is called glycogen synthase kinase, or GSK3, and blocking it might be an effective way to treat this type of leukemia--for which chemotherapy is characteristically ineffective. Existing drugs used for bipolar disease seem to do a shaky but effective job.
Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway
sea-maid submitted, created time 3 months 5 days (www.nature.com)
Fanconi anemia (FA) is a genome instability syndrome that is characterized by progressive bone marrow failure and a high risk of cancer. FA patients are particularly susceptible to leukemia as well as squamous cell carcinomas (SCCs) of the head and neck, anogenital region and skin. This article details experiments exploring the up and downregulation of FA.
PML targeting eradicates quiescent leukaemia-initiating cells.
kavin submitted, created time 6 months 1 week (www.ncbi.nlm.nih.gov)
In this paper, the researchers define the critical role of the promyelocytic leukaemia protein (PML) tumor suppressor in hematopoietic stem cell maintenance, and present a new therapeutic approach for targeting quiescent leukemia-initiating cells and possibly cancer-initiating cells by pharmacological inhibition of PML.
Mutation May Explain Deadly Form of Leukemia
Sue Wu submitted, created time 7 months 1 week (sciencenow.sciencemag.org)
A new study indicates that mutations in the Ikaros gene play a role in triggering acute lymphoblastic leukemia (ALL), an aggressive, treatment-resistant form of cancer.
Sue Wu submitted, created time 8 months 1 day (www.sciencedaily.com)
Individuals with a number of life-threatening genetic diseases of the immune system have been successfully treated by gene therapy
-- that is, they were infused with early precursors of immune cells that had the correct form of the defective gene delivered into them by agents known as retroviral vectors. However, many of them also developed leukemia.
Tracking Leukemia's Starting Point
sumsung submitted, created time 10 months 1 day (sciencenow.sciencemag.org)
Like all cancers, childhood leukemia starts silently, and how it begins is a perennial puzzle. Some leukemias have been tied to cancer "stem cells" that may drive the early stages of illness and possibly induce relapses. Now researchers in the U.K., Italy, and Japan say they've discovered a stem cell for the most common form of childhood leukemia. Helping them were twin girls, one of whom has the disease and one of whom is healthy.
Twins, one with leukemia, illustrate cancer stem cell hypothesis
Darkfrog submitted, created time 10 months 3 days (www.nature.com)
Cancer stem cell hypothesis is the idea that some cancers, including leukemia, are caused by a small number of cancer stem cells. Even if the majority of the tumor is removed of zapped with chemo, the cancer will recur unless the cancer stem cells are dispatched.
The twin girls in this study are fraternal, not identical, and one of them has leukemia and the other does not. However, a group of cells in the healthy girl, Isabella, seemed to match the ill girl, Olivia, implying that they were transferred to her while the two of them were developing. Some of these cells were removed
Gene Therapy Cancers Prompt Design of Safer Virus
Eric wu submitted, created time 10 months 1 week (sciencenow.sciencemag.org)
The announcement last month that a fifth child who received gene therapy for an immune system disease has developed leukemia was the latest blow to the field of gene therapy. But there's new hope: The U.K. team running the trial reports this week that a safer formulation of the treatment can cure the disease in mice and should also work in people.
This may be a new angle to prove security of gene therapy......
Good News:Transplants Without Tears
Eric wu submitted, created time 11 months 3 weeks (sciencenow.sciencemag.org)
A new treatment might allow patients to avoid some of the grueling side effects of bone marrow transplants. Researchers reported in the 23 November issue of Science that they can use a specific type of antibody to clear away old marrow stem cells in mice, allowing fresh ones to take their place. The discovery could allow patients to receive bone marrow without undergoing chemotherapy and other toxic procedures.
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
bianjie submitted, created time 1 year 4 months (www.pnas.org)
Arsenic trioxide (ATO) is an effective cancer therapeutic drug for acute promyelocytic leukemia and has potential anticancer activity against a wide range of solid tumors. ATO exerts its effect mainly through elevated oxidative stress, but the exact molecular mechanism remains elusive.
Gene's activity points to more lethal subtype of AML
bianjie submitted, created time 1 year 4 months (www.biologynews.net)
A new study shows that the activity of a particular gene can identify people who have a more lethal form of acute myeloid leukemia, singling out those patients who should receive more intense therapy.
Scientists gain important insights into acute promyelocytic leukemia
bianjie submitted, created time 1 year 4 months (www.eurekalert.org)
Results from two new studies provide key mechanistic insights into the complex molecular events that cause a deadly type of leukemia. The research, published in the July issue of the journal Cancer Cell, published by Cell Press, illuminates specific mechanisms involved in development of acute promyelocytic leukemia and identifies promising new avenues to develop treatments for some of its variant forms.
dovechocolate submitted, created time 1 year 5 months (bloodjournal.hematologylibrary.org)
Childhood T cell precursor (TCP) ALL is an aggressive disease with a presumably short latency that differs in many biological respects from B cell precursor (BCP) ALL. We therefore addressed the issue of in utero origin of this particular type of leukemia by tracing oncogenic mutations and clone-specific molecular markers back to birth.
abuse@discover8.com
angelfish
jane2007
DanyC
addict
Eotaxin is a 74 amino acid, eosinophil chemotactic CC chemok ...
www.genscript.com
dNTP (10 mM each) >98% HPLC
10 mM dNTP Mix is suitable for use in PCR, sequencing, nick ...
www.genscript.com
Rabbit Anti HSF1 (Ab-303) (Polyclonal)
antibody : Rabbit Anti HSF1 (Ab-303) (Polyclonal)
www.genscript.com
Lentiviral Vector Services
The LV preparation is similar to the production of simple re ...
www.genscript.com