PML targeting eradicates quiescent leukaemia-initiating cells.

kavin submitted, created time 7 months 3 weeks (www.ncbi.nlm.nih.gov)

In this paper, the researchers define the critical role of the promyelocytic leukaemia protein (PML) tumor suppressor in hematopoietic stem cell maintenance, and present a new therapeutic approach for targeting quiescent leukemia-initiating cells and possibly cancer-initiating cells by pharmacological inhibition of PML.

Submit comment | Blog It | Email It | Keywords: leukemia cancer oncogenesis cancer-initiating cell leukemia-initiating cell PML