Skin makes embryonic stem cells

captainclaw submitted, created time 1 year 5 months (www.abc.net.au)

Researchers have taken ordinary skin cells from a mouse and reprogrammed them to look and act like embryonic stem cells in a long-promised experiment that provides an alternative way to get these valued and controversial cells.

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Stem cell eye repair discovery

crackpot submitted, created time 1 year 6 months (www.news.com.au)

STEM cells made from human embryos can home in on damaged eyes, hearts and arteries of mice and rats, and appear to start repairs, a US company says. Massachusetts-based Advanced Cell Technology said it had devised a straightforward way to make blood vessel precursor cells out of the stem cells and plans to test them in humans.

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Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells

newsdigg submitted, created time 1 year 7 months (bloodjournal.hematologylibrary.org)

Development of kinase domain mutations is a major drug-resistance mechanism for tyrosine kinase inhibitors (TKIs) in cancer therapy. A particularly challenging example is found in Philadelphia chromosome-positive chronic myelogenous leukemia (CML) where all available kinase inhibitors in clinic are ineffective against the BCR-ABL mutant, T315I. As an alternative approach to kinase inhibition, an orally administered heat shock protein 90 (Hsp90) inhibitor, IPI-504, was evaluated in a murine model of CML

Submit comment | Blog It | Email It | Keywords: chronic myelogenous leukemia (CML) leukemic stem cells heat shock protein