Articles with the keyword:
7

ETosis: A Novel Cell Death Pathway

jerry submitted, created time 5 months 2 weeks (stke.sciencemag.org)

The formation of extracellular traps (ETs) by neutrophils and mast cells is an important mechanism in the innate immune response. These structures consist of a chromatin-DNA backbone with attached antimicrobial peptides and enzymes that trap and kill microbes. After stimulation of neutrophils and mast cells with phorbol esters, chemoattractant peptides, or chemokines, the generation of reactive oxygen species (ROS), such as hydrogen peroxide, by NAPDH oxidase initiates a signaling cascade that leads to the disintegration of the nuclear and cellular membranes and the formation of ETs

18

In Vivo Migration: A Germ Cell Perspective

BIOBOSS submitted, created time 1 year 9 months (www.biology.ucsd.edu)

[Full Text]The basic concepts of the molecular machinery that mediates cell migration have been gleaned from cell culture systems. However, the three-dimensional environment within an organism presents migrating cells with a much greater challenge. They must move between and among other cells while interpreting multiple attractive and repulsive cues to choose their proper path. They must coordinate their cell adhesion with their surroundings and know when to start and stop moving

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