Sleep Deprivation for Germs

davidd submitted, created time 8 months 2 weeks (sciencenow.sciencemag.org)

Most antibiotics kill only microbes that are growing and multiplying, leaving untouched a select few that are hibernating. A new study suggests that a dose of the right nutrients can awaken these bacteria for just long enough to kill them with antibiotics.

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CLOCK-mediated acetylation of BMAL1 controls circadian function

Sue Wu submitted, created time 1 year 2 weeks (www.nature.com)

Regulation of circadian physiology relies on the interplay of interconnected transcriptional–translational feedback loops. The CLOCK–BMAL1 complex activates clock-controlled genes, including cryptochromes (Crys), the products of which act as repressors by interacting directly with CLOCK–BMAL1.

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