Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p

franklin submitted, created time 1 year 3 months (www.pnas.org)

Proteins conjugated by Lys-48-linked polyubiquitin chains are preferred substrates of the eukaryotic proteasome. Polyubiquitination requires an activating enzyme (E1), a conjugating enzyme (E2), and a ligase (E3).

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Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair

medal submitted, created time 1 year 8 months (www.cell.com)

"Fanconi anemia (FA) is a developmental and cancer-predisposition syndrome caused by mutations in genes controlling DNA interstrand crosslink repair. Several FA proteins form a ubiquitin ligase that controls monoubiquitination of the FANCD2 protein in an ATR-dependent manner. "

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