The branching program of mouse lung development

kavin submitted, created time 8 months 1 hour (www.nature.com)

Mammalian lungs are branched networks containing thousands to millions of airways arrayed in intricate patterns that are crucial for respiration. The paper presents the complete three-dimensional branching pattern and lineage of the mouse bronchial tree, reconstructed from an analysis of hundreds of developmental intermediates. It also proposes that each mode of branching is controlled by a genetically encoded subroutine, a series of local patterning and morphogenesis operations.

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Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

athena submitted, created time 1 year 9 months (www.genesdev.org)

"Somatic activation of Ras occurs frequently in human cancers, including one-third of lung cancers. Activating Ras mutations also occur in the germline, leading to complex developmental syndromes. The precise mechanism by which Ras activation results in human disease is uncertain."

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