Molecular imaging of membrane interfaces reveals mode of β-glucosidase activation by saposin C

stephen submitted, created time 1 year 2 months (www.pnas.org)

Acid β-glucosidase (GCase) is a soluble lysosomal enzyme responsible for the hydrolysis of glucose from glucosylceramide and requires activation by the small nonenzymatic protein saposin C (sapC) to gain access to the membrane-embedded glycosphingolipid substrate.

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Epinephrine enhances lysosomal enzyme delivery across the blood-brain barrier by up-regulation of the mannose 6-phosphate receptor

bianjie submitted, created time 1 year 5 months (www.pnas.org)

Delivering therapeutic levels of lysosomal enzymes across the blood-brain barrier (BBB) has been a pivotal issue in treating CNS storage diseases, including the mucopolysaccharidoses.

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