Bcl-2-Regulated Calcium Signals as Common Mediators of Both Apoptosis and Autophagy

Vincent submitted, created time 9 months 3 weeks (www.sciencedirect.com)

Macroautophagy is an evolutionary conserved lysosomal pathway involved in the turnover of cellular macromolecules and organelles. In spite of its essential role in tissue homeostasis, the molecular mechanisms regulating mammalian macroautophagy are poorly understood. Here, we demonstrate that a rise in the free cytosolic calcium ([Ca2+]c) is a potent inducer of macroautophagy

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THE ESCRT COMPLEXES: Structure and Mechanism of a Membrane-Trafficking Network

biscuits submitted, created time 1 year 11 months (cmm.ucsd.edu:16080)

[Full Text]The ESCRT complexes and associated proteins comprise a major pathway for the lysosomal degradation of transmembrane proteins and are critical for receptor downregulation, budding of the HIV virus, and other normal and pathological cell processes. The ESCRT complexes form a network that recruits monoubiquitinated proteins and drives their internalization into lumenal vesicles within a type of endosome known as a multivesicular body.

Submit comment | Blog It | Email It | Keywords: ubiquitin sorting endocytosis lysosomes