Articles with the keyword: 
No place to hide for herpes virus
sea-maid submitted, created time 3 months 3 days (www.newscientist.com)
They say the difference between herpes and love is that herpes lasts forever. But new research hints at a way to chase the cold sore virus from its hiding place and get rid of it for good. 
The mechanics of translocation
jerry submitted, created time 4 months 4 days (www.sciencedirect.com)
Stepwise addition of amino acids to the growing polypeptide chain requires the coordinated movement of mRNA and tRNAs through the ribosome, a process known as translocation. Researchers review current understanding of the kinetics and mechanics of translocation, with emphasis on the structure of a functional mammalian ribosome stalled during translocation by an mRNA pseudoknot.
Translation factors promote the formation of two states of the closed-loop mRNP
kavin submitted, created time 4 months 1 week (www.ncbi.nlm.nih.gov)
In the paper, the authors use toeprinting and polysome profiling assays to delineate ribosome positioning at initiator AUG codons and ribosome-mRNA association, respectively, and find that two distinct stable (resistant to cap analogue) closed-loop structures are formed during initiation in yeast cell-free extracts. The integrity of both forms requires the mRNA cap and poly(A) tail, as well as eIF4E, eIF4G, Pab1 and eIF3, and is dependent on the length of both the mRNA and the poly(A) tail.
A Test of the Null Model for 5' UTR Evolution Based on GC Content
sea-maid submitted, created time 4 months 4 weeks (mbe.oxfordjournals.org)
Eukaryotic mRNAs are headed by a stretch of noncoding sequence, the 5' untranslated region (UTR). It has been proposed that the length of 5' UTRs is selectively neutral and evolves under a process of stochastic destruction and recruitment of core promoter elements, combined with selection against the premature initiation of translation. The authors of this research test this null model by investigating whether 5' UTR length varies with genomic GC content, an implicit prediction of the model.
First direct observations of protein-synthesis mechanism
jane2007 submitted, created time 6 months 2 days (www.ucsc.edu)
An UCSC scientist and his collaborators have made the first direct observations of the mechanism for protein synthesis in living cells.
Research sheds light on the mechanics of gene transcription
jane2007 submitted, created time 8 months 4 weeks (www.news.cornell.edu)
The molecular machinery behind gene transcription -- the intricate transfer of information from a segment of DNA to a corresponding strand of messenger RNA -- isn't stationed in special "transcription factories" within a cell nucleus, according to Cornell researchers. Instead, the enzyme RNA polymerase II (Pol II) and other key molecules can assemble at the site of an activated gene, regardless of the gene's position.
DanyC submitted, created time 11 months 1 week (www.jcb.org)
"The retained mRNAs maintain the ability to recruit components of the exon junction complex and the nuclear exosome subunit Rrp6p, suggesting that binding of these proteins is not sufficient for RNA release. Researchers propose that the missing heptads in the truncated CTD mutant are required for binding of proteins implicated in a final co-transcriptional maturation of spliced and 3' end cleaved and polyadenylated mRNAs into export-competent ribonucleoprotein particles."
Structured mRNAs Regulate Translation Initiation by Binding to the Platform of the Ribosome
DanyC submitted, created time 1 year 3 days (www.cell.com)
"Here, researchers report a series of cryo-electron microscopy snapshots of ribosomal complexes directly visualizing either the mRNA structure blocked by repressor protein S15 or the unfolded, active mRNA. In the stalled state, the folded mRNA prevents the start codon from reaching the peptidyl-tRNA (P) site inside the ribosome. Upon repressor release, the mRNA unfolds and moves into the mRNA channel allowing translation initiation. "
Sumoylation in axons triggers retrograde transport of the RNA-binding protein La
bianjie submitted, created time 1 year 2 months (www.pnas.org)
A surprisingly large population of mRNAs has been shown to localize to sensory axons, but few RNA-binding proteins have been detected in these axons. These axonal mRNAs include several potential binding targets for the La RNA chaperone protein.
Reviver submitted, created time 1 year 2 months (www.pnas.org)
"Researchers found that the assembly of the EJC onto mRNA occurs at the late stages of the splicing reaction and requires the second-step splicing and mRNA-release factor HRH1/hPrp22. The EJC-dependent and -independent recruitment of RNA-binding proteins onto mRNA suggests a role for the EJC in messenger ribonucleoprotein remodeling involving interactions with other proteins already bound to the pre-mRNA, which has implications for nonsense-mediated mRNA decay and other mRNA transactions."
Tissue-specific mRNA expression profiling in grape berry tissues
annatto submitted, created time 1 year 3 months (www.biomedcentral.com)
"These results revealed novel insights into the tissue-specific expression mRNA expression patterns of an extensive repertoire of genes expressed in berry tissues. This work also establishes an extensive catalogue of gene expression patterns for future investigations aimed at the dissection of the transcriptional regulatory hierarchies that govern tissue-specific expression patterns associated with tissue differentiation within berries
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