Articles with the keyword: 
Gene Targeting Discovery Opens Door for Vaccines and Drugs
piggy submitted, created time 11 months 1 week (www.sciencedaily.com)
In a genetic leap that could help fast-track vaccine and drug development, DMS researchers have discovered how to destroy a key DNA pathway in a wily and widespread human parasite. The feat surmounts a major hurdle for targeting genes in Toxoplasma gondii, an infection model whose close relatives are responsible for diseases that include malaria and severe diarrhea 
sea-maid submitted, created time 11 months 1 week (www.nature.com)
Antimalarial compound fights disease and fends off drug-resistant parasites in mice.
Virus's Achilles' Heel Revealed
piggy submitted, created time 1 year 1 month (sciencenow.sciencemag.org)
Scientists have made a discovery about the basic biology of the Nipah virus, which suggests that cheap, existing drugs for high blood pressure and malaria may help fight the disease. Nipah regularly strikes in rural Bangladesh and neighboring parts of India. The new insights about the deadly pathogen, announced here on 14 February at the International Meeting on Emerging Infectious Diseases and Surveillance, could lead to the first human drug studies within a year, scientists say
Mosquito genes could be target in malaria fight
sea-maid submitted, created time 1 year 1 month (www.newsdaily.com)
Researchers say they have identified genes that make some African malaria-carrying mosquitoes resistant to insecticide, and hope the breakthrough could boost efforts to prevent the deadly disease.
New Pathway for Malaria Infection Discovered
sea-maid submitted, created time 1 year 6 months (www.sciencedaily.com)
Cenix BioScience GmbH, a leading specialist in advanced RNA interference (RNAi)-based research services, Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, and the Lisbon-based biomedical research centre Instituto de Medicina Molecular (IMM), have announced the publication of their collaborative study in Cell Host & Microbe, describing the discovery and in vivo validation of scavenger receptor BI (SR-BI), a major regulator of cholesterol uptake by the liver, as a critical host factor for malaria infection.
Genetic Variant Raises HIV Risk
sea-maid submitted, created time 1 year 8 months (www.time.com)
There's no doubt Africans have borne the brunt of the AIDS epidemic. Now researchers in London and Texas say it may have something to do with a single gene variant that could account for 11%, or about 2.5 million, of Africa's HIV cases.
sea-maid submitted, created time 1 year 8 months (www.sciencenews.org)
Battling malaria for millennia helped Africans build barriers against the parasite that causes it, but that defense has proven to be a double-edged sword for HIV infection. One protein, the Duffy antigen receptor for cytokines, protects against malaria by making the individual more susceptible to contracting HIV. However, those same individuals do live longer once infected.
Synthetic yeast to brew up vital malaria drug
jerry submitted, created time 1 year 9 months (www.newscientist.com)
A partly artificial organism could be producing enough of a key malaria drug to treat the world within three years...
Searching for a better mosquito repellent
sea-maid submitted, created time 1 year 9 months (www.pnas.org)
Most people in hot places--or even just hot weather--are troubled by mosquitos. What is an annoyance in some parts of the world, however, can be fatal in others. In this stuty, the scientists point out that it is necessary to search for more effective repellents, one of which is introduced in this article, lasting a record 85 days!
New mesh gives net gains against mosquitoes
sea-maid submitted, created time 1 year 9 months (technology.newscientist.com)
Mosquitoes can carry many blood-borne diseases, like malaria and yellow fever. This study follows the introduction of: bed nets designed to stop mosquitoes in their tracks, which are undergoing large-scale trials in India and Tanzania.
Pyruvate Kinase Deficiency and Malaria
davidd submitted, created time 1 year 10 months (content.nejm.org)
Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and there is evidence of coevolution of the plasmodium parasite with its host. In humans, pyruvate kinase deficiency is the second most common erythrocyte enzyme disorder. Here, they show that pyruvate kinase deficiency provides protection against infection and replication of P
Good News: New Vaccines for Malaria and Other Diseases Are on the Way
siemens submitted, created time 1 year 11 months (www.sciencedaily.com)
Researchers in Colombia describe a new strategy for designing the next generation of synthetic vaccines that could lead to more effective treatments for fighting malaria, tuberculosis, AIDS and other infectious diseases. These conditions kill more than 17 million people around the world each year.
How sperm and egg fuse into one could have applications in antiparasitics
jane2007 submitted, created time 1 year 11 months (www.nature.com)
How do sperm and egg fuse into one? A protein called HAP2 is involved with the fusion of egg and sperm in a wide range of species. This fusion protein could be targeted to stop parasites from reproducing.
Lending a Helping Arm to Malaria Vaccine
Sue Wu submitted, created time 2 years 2 weeks (www.sciam.com)
Researchers announced today that they are building a new facility dedicated to finding an effective vaccine against malaria, a potentially deadly disease spread by mosquitoes that annually strikes some 500 million worldwide and kills as many as one million people, mostly children in Africa.
davidd submitted, created time 2 years 3 weeks (www.nature.com)
How many people contract malaria? Which places are hardest hit? Has incidence or mortality been cut much in the past decades? Which has been more successful: prevention or treatment? How do you prevent malaria infections? What about making genetically modified mosquitoes that can't carry the disease?
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