Nuclear import of influenza A viral ribonucleoprotein complexes is mediated by two nuclear localization sequences on viral nucleoprotein

annatto submitted, created time 1 year 7 months (www.virologyj.com)

"According to researchers results demonstrate that both NLS1 and NLS2 on NP can mediate the nuclear uptake of influenza A vRNPs."

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Binding of the Human Prp31 Nop Domain to a Composite RNA-Protein Platform in U4 snRNP

newsdigg submitted, created time 1 year 9 months (www.sciencemag.org)

Although highly homologous, the spliceosomal hPrp31 and the nucleolar Nop56 and Nop58 (Nop56/58) proteins recognize different ribonucleoprotein (RNP) particles. hPrp31 interacts with complexes containing the 15.5K protein and U4 or U4atac small nuclear RNA (snRNA), whereas Nop56/58 associate with 15.5K–box C/D small nucleolar RNA complexes. We present structural and biochemical analyses of hPrp31-15.5K-U4 snRNA complexes that show how the conserved Nop domain in hPrp31 maintains high RNP binding selectivity despite relaxed RNA sequence requirements

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