TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

kavin submitted, created time 6 months 2 weeks (www.cell.com)

It is known that immune homeostasis is essential for the normal functioning of the immune system, and its breakdown leads to fatal inflammatory diseases. In this paper, the authors found that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis.

3 comments | Blog It | Email It | Keywords: TLR TCR homeostasis negative feedback TIPE2 Immune Function Immune System Enzyme mammalian immune system immune system innate immune system TIPE2 Immune Homeostasis

Regulation of the Germinal Center Response by MicroRNA-155

cappuccion submitted, created time 1 year 6 months (www.sciencemag.org)

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production

Submit comment | Blog It | Email It | Keywords: MicroRNA-155 mammalian differentiation processes mammalian immune system