Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors

davis submitted, created time 1 year 2 months (www.pnas.org)

Human colonic epithelial cell renewal, proliferation, and differentiation are stringently controlled by numerous regulatory pathways. To identify genetic programs of human colonic epithelial cell differentiation in vivo as well as candidate marker genes that define colonic epithelial stem/progenitor cells and the stem cell niche, we applied gene expression analysis of normal human colon tops and basal crypts by using expression microarrays with 30,000 genes.

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