A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

dedu submitted, created time 1 year 4 weeks (www.cell.com)

“Epithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic cell death program termed anoikis. Michael et al. describe a nonapoptotic cell death program in matrix-detached cells that is initiated by a previously unrecognized and unusual process involving the invasion of one cell into another, leading to a transient state in which a live cell is contained within a neighboring host cell. Live internalized cells are either degraded by lysosomal enzymes or released

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