Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3

Captnimbus submitted, created time 1 year 6 months (www.fasebj.org)

Medulloblastoma, the most common brain tumor in childhood, appears to originate from cerebellar granule cell precursors (GCPs), located in the external granular layer (EGL) of the cerebellum. The antiproliferative gene PC3 (Tis21/BTG2) promotes cerebellar neurogenesis by inducing GCPs to shift from proliferation to differentiation

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Repair of DNA by Brca2 gene prevents medulloblastoma

badboy submitted, created time 1 year 7 months (www.biologynews.net)

"Investigators at St. Jude Children's Research Hospital have gained some of the first major insights into how certain genes known to prevent cancer also guide the normal development of the nervous system before birth and during infancy by repairing DNA damage."

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