Articles with the keyword: 
Tension gets chromosomes oriented
sea-maid submitted, created time 7 months 2 days (www.jcb.org)
Using grasshopper cells in meiosis, Bruce Nicklas and Carol Koch show that attachments of mono-oriented chromosomes can be stabilized using a glass needle to pull on one of the chromosomes.
Thus tension between two kinetochores, generated only in the bi-oriented state, might discriminate between correct and incorrect attachments. 
Structure, dynamics, and evolution of centromeric nucleosomes
jimmy submitted, created time 1 year 3 months (www.pnas.org)
Centromeres are defining features of eukaryotic chromosomes, providing sites of attachment for segregation during mitosis and meiosis. The fundamental unit of centromere structure is the centromeric nucleosome, which differs from the conventional nucleosome by the presence of a centromere-specific histone variant (CenH3) in place of canonical H3.
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A
franklin submitted, created time 1 year 3 months (www.pnas.org)
Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive state. It was recently reported that Mos, an integral component of CSF, acts in part by promoting the Rsk-mediated phosphorylation of the APC inhibitor Emi2/Erp1.
Luneetty submitted, created time 1 year 9 months (www.pnas.org)
Modeling and analysis of genetic regulatory networks is essential both for better understanding their dynamic behavior and for elucidating and refining open issues. We hereby present a discrete computational model that effectively describes the transient and sequential expression of a network of genes in a representative developmental pathway. Our model system is a transcriptional cascade that includes positive and negative feedback loops directing the initiation and progression through meiosis in budding yeast
Critical roles for Dicer in the female germline
athena submitted, created time 1 year 9 months (www.genesdev.org)
"Dicer is an essential component of RNA interference (RNAi) pathways, which have broad functions in gene regulation and genome organization. Probing the consequences of tissue-restricted Dicer loss in mice indicates a critical role for Dicer during meiosis in the female germline."
Dolly submitted, created time 1 year 9 months (www.jcb.org)
Homologue segregation during the first meiotic division requires the proper spatial regulation of sister chromatid cohesion and its dissolution along chromosome arms, but its protection at centromeric regions. This protection requires the conserved MEI-S332/Sgo1 proteins that localize to centromeric regions and also recruit the PP2A phosphatase by binding its regulatory subunit, Rts1. Centromeric Rts1/PP2A then locally prevents cohesion dissolution possibly by dephosphorylating the protein complex cohesin
julie submitted, created time 1 year 9 months (www.molecule.org)
"Progression through meiosis in yeast is governed by the cyclin-dependent kinase Cdk1, in concert with a related kinase called Ime2. It remains unclear how these kinases collaborate to meet the unique demands of meiotic progression. "
alpha submitted, created time 1 year 9 months (www.jcb.org)
"Synapsis is the process by which paired chromosome homologues closely associate in meiosis before crossover. In the synaptonemal complex (SC), axial elements of each homologue connect through molecules of SYCP1 to the central element, which contains the proteins SYCE1 and -2. We have derived mice lacking SYCE2 protein, producing males and females in which meiotic chromosomes align and axes form but do not synapse. Sex chromosomes are unaligned, not forming a sex body
Meiotic Pairing: A Place to Hook up
athena submitted, created time 1 year 9 months (www.current-biology.com)
At one end of each Caenorhabditis elegans chromosome is a locus required for meiotic crossing over. Recent studies have shown that these sites mediate chromosome pairing and synapsis during meiosis, and that each site contains binding sites for a non-canonical C2H2 zinc finger protein
cappuccion submitted, created time 1 year 9 months (www.sciencedirect.com)
Progression through meiosis in yeast is governed by the cyclin-dependent kinase Cdk1, in concert with a related kinase called Ime2. It remains unclear how these kinases collaborate to meet the unique demands of meiotic progression. Ime2 and Cdk1 phosphorylate an overlapping substrate set and that the two kinases overlap functionally as inhibitors of the ubiquitin ligase APCCdh1 and replication origin licensing. Surprisingly, Ime2 phosphorylates Cdk1 substrates at distinct phosphorylation sites that are highly resistant to dephosphorylation by the phosphatase Cdc14
Aurora B Needs Monopolin in Meiosis
Admin submitted, created time 1 year 10 months (www.cell.com)
Kinetochores of sister chromatids attach to microtubules emanating from the same pole (coorientation) during meiosis I and microtubules emanating from opposite poles (biorientation) during meiosis II. The scientists find that the Aurora B kinase Ipl1 regulates kinetochore-microtubule attachment during both meiotic divisions and that a complex known as the monopolin complex ensures that the protein kinase coorients sister chromatids during meiosis I
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