Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats

jerry submitted, created time 4 months 3 weeks (diabetes.diabetesjournals.org)

The worldwide prevalence of obesity is increasing at an alarming rate, along with the associated increased rates of type 2 diabetes, heart disease, and some cancers. While efforts to address environmental factors responsible for the recent epidemic must continue, investigation into the anorectic functions of potential molecules they present in this paper, such as apolipoprotein (apo) E, offers exciting possibilities for future development of successful anti-obesity therapies

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Importance of Melanocortin Signaling

amanda submitted, created time 1 year 10 months (endo.endojournals.org)

"Compared with fed and fasted animals, a significant increase (P < 0.001) in the number of c-Fos-immunoreactive cells was identified in refed animals in the supraoptic nucleus, magnocellular and ventral parvocellular subdivisions of the hypothalamic paraventricular nucleus (PVNv), and the dorsal and ventral subdivisions of the dorsomedial nucleus (DMNd and DMNv, respectively). "

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