CD4+ T cell memory determinant

Affinity of antigen encounter and other early B-cell signals determine B-cell fate

athena submitted, created time 1 year 7 months (www.sciencedirect.com)

"Three possible effector fates await the naïve follicular B cell following antigen stimulation in thymus-dependent reactions. Short-lived plasma cells produce an initial burst of germline-encoded protective antibodies, and long-lived plasma cells and memory B cells arise from the germinal center and function to enhance and sustain the humoral immune response."

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