The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels

stephen submitted, created time 1 year 3 months (www.pnas.org)

Metabolic fluxes may be regulated "hierarchically," e.g., by changes of gene expression that adjust enzyme capacities (Vmax) and/or "metabolically" by interactions of enzymes with substrates, products, or allosteric effectors.

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Quantitative characterization of cell synchronization in yeast

sumsung submitted, created time 1 year 5 months (www.pnas.org)

Metabolic oscillations in baker's yeast serve as a model system for synchronization of biochemical oscillations. Despite widespread interest, the complexity of the phenomenon has been an obstacle for a quantitative understanding of the cell synchronization process.

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Metabolic plasticity during mammalian development is directionally dependent on early nutritional status

sumsung submitted, created time 1 year 5 months (www.pnas.org)

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for most mammalian traits.

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The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

sumsung submitted, created time 1 year 5 months (www.pnas.org)

We examined the hypothesis that insulin resistance in skeletal muscle promotes the development of atherogenic dyslipidemia, associated with the metabolic syndrome, by altering the distribution pattern of postprandial energy storage.

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Metabolic switch delivers healthy fat

bianjie submitted, created time 1 year 5 months (www.bioedonline.org)

Researchers have identified a cellular switch that triggers the production of 'good' fat cells, which pump out heat and raise the body's metabolic rate. The discovery, made in mice, might one day provide a way to treat or prevent obesity in humans.

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What are the metabolic costs of digesting a meal?

mmccue submitted, created time 1 year 6 months (comp.uark.edu)

All animals incur unavoidable metabolic costs associated with digesting food which take away from their net energy gains, a phenomenon is known as specific dynamic action (SDA). Interestingly, despite a century of inquiry, modern scientists cannot agree on exactly why this is. This review summarizes the history of physiological and nutritional inquiries into SDA, and discuses the various hypotheses that have been advanced to SDA throughout the decades

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Metabolic engineering of Escherichia coli for the production of L-valine

yoyotaxi submitted, created time 1 year 7 months (www.pnas.org)

The L-valine production strain of Escherichia coli was constructed by rational metabolic engineering and stepwise improvement based on transcriptome analysis and gene knockout simulation of the in silico genome-scale metabolic network. Results suggest that an industrially competitive strain can be efficiently developed by metabolic engineering based on combined rational modification, transcriptome profiling, and systems-level in silico analysis.

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Twin Studies Identify Influences of Heredity, Environment, and Adrenergic Pathway Polymorphism

julie submitted, created time 1 year 8 months (hyper.ahajournals.org)

"Albumin excretion marks early glomerular injury in hypertension. This study investigated heritability of albumin excretion in twin pairs and its genetic determination by adrenergic pathway polymorphism. Genetic associations used single nucleotide polymorphisms at adrenergic pathway loci spanning catecholamine biosynthesis, storage, catabolism, receptor action, and postreceptor signal transduction."

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