What are the metabolic costs of digesting a meal?

mmccue submitted, created time 1 year 6 months (comp.uark.edu)

All animals incur unavoidable metabolic costs associated with digesting food which take away from their net energy gains, a phenomenon is known as specific dynamic action (SDA). Interestingly, despite a century of inquiry, modern scientists cannot agree on exactly why this is. This review summarizes the history of physiological and nutritional inquiries into SDA, and discuses the various hypotheses that have been advanced to SDA throughout the decades

Submit comment | Blog It | Email It | Keywords: metabolic regulation metabolic disorder metabolic Metabolic syndrome intestinal metabolic function metabolic disorders metabolic acidosis review digestion, energetic costs, postprandial specific dynamic action

Acidosis-Sensing Glutamine Pump SNAT2 Determines Amino Acid Levels and Mammalian Target of Rapamycin Signalling to Protein Synthesis in L6 Muscle Cells

alpha submitted, created time 1 year 8 months (jasn.asnjournals.org)

"Wasting of lean tissue as a consequence of metabolic acidosis is a serious problem in patients with chronic renal failure. A possible contributor is inhibition by low pH of the System A (SNAT2) transporter, which carries the amino acid L-glutamine (L-Gln) into muscle cells."

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Distal Renal Tubular Acidosis in Mice Lacking the AE1 (Band3) Cl–/HCO3– Exchanger (slc4a1)

medal submitted, created time 1 year 8 months (jasn.asnjournals.org)

"Mutations in the human gene that encodes the AE1 Cl–/HCO3– exchanger (SLC4A1) cause autosomal recessive and dominant forms of distal renal tubular acidosis (dRTA). A mouse model that lacks AE1/slc4a1 (slc4a1–/–) exhibited dRTA characterized by spontaneous hyperchloremic metabolic acidosis with low net acid excretion and, inappropriately, alkaline urine without bicarbonaturia. Basolateral Cl–/HCO3– exchange activity in acid-secretory intercalated cells of isolated superfused slc4a1–/– medullary collecting duct was reduced, but alternate bicarbonate transport pathways were upregulated."

Submit comment | Blog It | Email It | Keywords: renal tubular acidosis AE1 metabolic acidosis