Selective Tuning of the Blood Oxygenation Level-Dependent Response during Simple Target Detection Dissociates Human Frontoparietal Subregions

Reviver submitted, created time 1 year 6 months (www.jneurosci.org)

"Current models of working memory and focal attention converge on the idea of an adaptable global system, distributed across a network of frontal and parietal brain regions. Here, researchers examine how the human frontoparietal network selectively adapts to represent currently relevant information during a simple attentional task: monitoring for a target item in a series of nontargets. Across the entire frontoparietal network, there is selective response to targets, in line with a global system for coding task-relevant inputs

Submit comment | Blog It | Email It | Keywords: target recognition domains (TRDs) metabolic network frontal cortex parietal cortex fMRI

Multiple High-Throughput Analyses Monitor the Response of E. coli to Perturbations

addict submitted, created time 1 year 8 months (www.sciencemag.org)

Analysis of cellular components at multiple levels of biological information can provide valuable functional insights. We performed multiple high-throughput measurements to study the response of Escherichia coli cells to genetic and environmental perturbations. Analysis of metabolic enzyme gene disruptants revealed unexpectedly small changes in messenger RNA and proteins for most disruptants. Overall, metabolite levels were also stable, reflecting the rerouting of fluxes in the metabolic network. In contrast, E