Articles with the keyword: 
Alzheimer's Gene Slows Brain's Ability to Export Toxic Protein
piggy submitted, created time 2 weeks 3 days (www.sciencedaily.com)
The only known genetic risk factor for Alzheimer's disease slows down the brain's ability to export a toxic protein known as amyloid-beta that is central to the damage the disease causes, scientists have found.
The research, published Nov. 13 by the Journal of Clinical Investigation, provides new clues into the workings of a protein known as apolipoprotein E4, or ApoE4. People who carry two copies of the gene have roughly eight to ten times the risk of getting Alzheimer's disease than people who do not 
GlaxoSmithKline's customized "red wine" drug potent in mice
piggy submitted, created time 3 weeks 4 days (www.reuters.com)
LONDON (Reuters) - A drug in development that mimics a health-boosting compound found in red wine may be a powerful weapon in the fight against obesity and diabetes, researchers said on Tuesday.
A study of mice showed that the GlaxoSmithKline drug SRT1720 was about a thousand times more potent than resveratrol in activating an enzyme that helped the animals burn more energy and lower their insulin and glucose levels
Madness: Price of a Big Brain?
sea-maid submitted, created time 3 months 3 weeks (sciencenow.sciencemag.org)
A new study suggests that the debilitating disease schizophrenia may be a byproduct of the genetic changes that fueled the evolution of the expansive human brain. The idea, still preliminary, is that the massive energy demands of the brain may make it vulnerable to mutations in metabolism-related genes.
Hot peppers really do bring the heat
sea-maid submitted, created time 3 months 3 weeks (www.eurekalert.org)
Researchers have found that capsaicin, the active chemical in chili peppers, can induce thermogenesis, the process by which cells convert energy into heat.
Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism
sea-maid submitted, created time 6 months 1 week (www.cellmetabolism.org)
Subcutaneous (SC) and visceral (VIS) obesity are associated with different risks of diabetes and the metabolic syndrome. And from this study, it suggests that SC fat is intrinsically different from VIS fat and produces substances that can act systemically to improve glucose metabolism.
MicroRNA Sets Stage for Human Therapies
sumsung submitted, created time 8 months 5 days (sciencenow.sciencemag.org)
Scientists have taken a big step toward developing therapies based on naturally occurring tiny RNA molecules called microRNAs. In the first successful experiment with primates, researchers have blocked microRNAs to lower cholesterol levels in monkeys. This achievement builds hope that the strategy could one day be used to attack human diseases. Safety concerns still linger, however.
Gene Therapy Could Cure GSD-Ia
Sue Wu submitted, created time 8 months 2 weeks (www.dukemednews.org)
A gene therapy treatment that restores a missing liver enzyme in test animals could provide a cure for a rare metabolic disorder in humans, according to Duke University Medical Center researchers.
Protein found to turn up metabolism in mice
Eric wu submitted, created time 11 months 3 weeks (www.reuters.com)
Tricking muscle tissue to burn rather than store fat has succeeded in increasing the average life span of mice and staved off some age-related diseases, U.S. researchers said on Tuesday.
Sex, Sugar And Metabolic Disease
jiangyun submitted, created time 1 year 3 weeks (www.scientificblogging.com)
Overweight children and adults have low levels in their blood of a protein known as SHGB, which transports sex steroids and regulates their entry into tissues. Low levels of SHGB are a marker of the metabolic syndrome, a combination of medical disorders that increase an individual’s risk of developing type 2 diabetes and heart disease.
Genomic analysis of human microRNA transcripts
jimmy submitted, created time 1 year 1 month (www.pnas.org)
MicroRNAs (miRNAs) are important genetic regulators of development, differentiation, growth, and metabolism. The mammalian genome encodes 500 known miRNA genes. Approximately 50% are expressed from non-protein-coding transcripts, whereas the rest are located mostly in the introns of coding genes.
MitoNEET is a uniquely folded 2Fe–2S outer mitochondrial membrane protein stabilized by pioglitazone
bianjie submitted, created time 1 year 3 months (www.pnas.org)
Iron–sulfur (Fe–S) proteins are key players in vital processes involving energy homeostasis and metabolism from the simplest to most complex organisms.
The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture
cappuccion submitted, created time 1 year 6 months (www.pnas.org)
Metabolism represents a complex collection of enzymatic reactions and transport processes that convert metabolites into molecules capable of supporting cellular life. Here we explore the origins and evolution of modern metabolism. Using phylogenomic information linked to the structure of metabolic enzymes, we sort out recruitment processes and discover that most enzymatic activities were associated with the nine most ancient and widely distributed protein fold architectures.
medal submitted, created time 1 year 7 months (www.jci.org)
"A novel antiinfective approach is to exploit stresses already imposed on invading organisms by the in vivo environment. Fe metabolism is a key vulnerability of infecting bacteria because organisms require Fe for growth, and it is critical in the pathogenesis of infections."
medal submitted, created time 1 year 7 months (aje.oxfordjournals.org)
"Nicotine metabolism has been hypothesized to affect patterns of smoking. The recent development of a noninvasive measure of nicotine metabolism, the nicotine metabolite ratio (trans-3'-hydroxycotinine/cotinine), makes it possible to examine the association between rate of nicotine metabolism and smoking behavior in the general population."
fiona submitted, created time 1 year 7 months (circ.ahajournals.org)
"Transport rates of long-chain free fatty acids into mitochondria via carnitine palmitoyltransferase I relative to overall oxidative rates in hypertrophied hearts remain poorly understood. Furthermore, the extent of glucose oxidation, despite increased glycolysis in hypertrophy, remains controversial. The present study explores potential compensatory mechanisms to sustain tricarboxylic acid cycle flux that resolve the apparent discrepancy of reduced fatty acid oxidation without increased glucose oxidation through pyruvate dehydrogenase complex in the energy-poor, hypertrophied heart."
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