Articles with the keyword: 
jerry submitted, created time 3 months 2 days (sciencenow.sciencemag.org)
A new study in lab mice suggests that cells may break off from a tumor even before they become cancerous, seeding the body with cells that evade detection and lie dormant for years before turning into tumors of their own. 
sea-maid submitted, created time 3 months 3 days (www.nature.com)
Non-cancerous mammary cells in mice can take up residence in the lungs and later form tumors. This chance of residence, called metastasis, had previously been thought nearly impossible for ordinary, healthy cells.
Virus helps show how cancer spreads
sea-maid submitted, created time 4 months 2 weeks (news.bbc.co.uk)
Scientists have used a common cold virus to "light up" prostate cancer tumors in different parts of the body. A University of California team has found that, when infected by a certain virus, mouse prostate cancer cells become remarkably easy to spot on scanners.
The research team says that the technique requires further development, but if these results extrapolate to humans, it could be a huge boon to cancer research, particularly in cases in which metastasis is suspected.
UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
kavin submitted, created time 4 months 2 weeks (newsroom.ucla.edu)
Using an engineered common cold virus, UCLA researchers delivered a genetic payload to prostate cancer cells that allowed them, using Positron Emission Tomography (PET), to locate the diseased cells as they spread to the lymph nodes, the first place prostate cancer goes before invading other organs.
The tiny cancer metastases in the pelvic lymph nodes are very difficult to find using conventional imaging tools such as CT scanning
New Weapon for Attacking Tumor Invasion and Metastasis
kavin submitted, created time 5 months 1 week (www.mphtimes.com)
A team led by Dr. Ji-Kun Li has determined that AMD3100, originally developed in acquired immune deficiency syndrome treatment, could markedly inhibit spreading of colorectal cancer cells by blocking a new pair of ligands and its unique receptor. This effect differs from the usual inhibition by a conventional chemotherapic agent that is more specific to cancer cells with high metastatic potential.
In vitro, AMD3100 has shown a significantly inhibitory effect on invasion and migration in colorectal cancer cell line. This effect can be further enhanced at higher concentration
sea-maid submitted, created time 5 months 2 weeks (www.nature.com)
Some tumours may stimulate the growth of distant cancers within the body. And it is very important for us to know this. We can take some measures to prevent the cancer efficiently. This article discusses some of the forms of early metastasis and tumor promotion by other tumors.
Frequent p16-Independent Inactivation of p14ARF in Human Melanoma
kavin submitted, created time 5 months 3 weeks (jnci.oxfordjournals.org)
In this paper, the authors observed two or more alterations to the ARF gene in 26/60 (43%) metastases. The p16 gene sustained two or more alterations in 13/60 (22%) metastases (P = .03). Inactivation of ARF in the presence of wild-type p16 was seen in 18/60 (30%) metastases. And the genetic and epigenetic analyses of the human 9p21 locus indicate that modifications of ARF occur independently of p16 inactivation in human melanoma and suggest that ARF is more frequently inactivated than p16.
Mitochondrial Mutations Make Tumors Spread
jane2007 submitted, created time 7 months 4 weeks (sciencenow.sciencemag.org)
Why is it that cancer often strikes its final, fatal blow when a tumor spreads to other organs? It's because of the metastasis of mitochondrial DNA mutations.
How Do Tumors Spread? Scientists and Engineers Team Up to Solve Mystery
davidd submitted, created time 8 months 2 weeks (www.sciam.com)
Nine out of every 10 cancer deaths occur because the disease has spread. Yet metastasis is the most poorly understood process in cancer biology.
A protein that makes breast cancer spread
jane2007 submitted, created time 8 months 2 weeks (www.nature.com)
A protein that determines whether breast cancer will spread and become deadly has been found. Monitoring for the protein could help patients to know how dangerous their cancer is before it spreads elsewhere and help them to decide which treatment to chose.
Epigenetic Regulation of EpCAM in Tumor Invasion and Metastasis
MedUnion submitted, created time 9 months 2 weeks (www.mupnet.com)
Metastatic progression is the cause of most cancer decease. Many cell surface adhesion molecules are known to be present or re-expressed following gene promoter CpG island hypomethylation in the early stage of growing tumors, but absent or reduced by gene promoter CpG hypermethylation in metastasized carcinomas. Recent studies have revealed that an adhesion receptor, epithelial cell adhesion molecule (EpCAM), mediates cell-cell interaction and is involved in tumor invasion and metastasis. EpCAM expression was associated with promoter CpG methylation in lung adenocarcinoma
Tumor Time Bombs Set Off by Stem Cells
sumsung submitted, created time 10 months 2 weeks (www.sciam.com)
Researchers say they have identified a switch that makes dormant breast cancer cells that have traveled to the lungs swell to lethal proportions—completing the dreaded process of metastasis or cancer spread.
MicroRNAs Keep Tumors in Place
Eric wu submitted, created time 10 months 3 weeks (sciencenow.sciencemag.org)
When a cancer spreads, or metastasizes, it often becomes incurable. Now scientists are eying a new factor that may prompt tumor cells to start roaming: a deficit of molecules known as microRNAs, which modulate gene expression. Building on earlier work linking microRNAs to cancer, researchers have found that a lack of certain microRNAs encourages tumors to spread. They also report that in mice, the microRNAs can be manipulated to slow metastasis.
I am very glad that this news has opened a path toward explaining the follow article 'Breast-Cancer Genes May Come With Lower Risk'
Elevation of Serum HSP90? Correlated with the Clinical Stage of Non-Small Cell Lung Cancer
MedUnion submitted, created time 1 year 2 months (www.mupnet.com)
AIM: The heat shock protein HSP90?, reportedly expressing in cytoplasm, had been recently detected in serum-free cultured medium (CM) from fibrosarcoma cells and breast adenocarcinoma cells. The present study was designed to investigate whether HSP90? could be found in the CM of lung cancer cell lines, and is a sensitive and specific serum biomarker for the diagnosis and progression of lung cancer
jiangyun submitted, created time 1 year 3 months (carcin.oxfordjournals.org)
The esophageal cancer related gene2 (ECRG2) is a novel gene which shows sequence similarity to KAZAL-type serine protease inhibitor. In this study, the migration and invasion of PG cancer cells were inhibited by ectopic expression of ECGR2 in vitro, and metastases decreased after injecting PG/pcDNA3.1-ECRG2 cells into the tail veins of nude mice.
abuse@discover8.com
angelfish
Darkfrog
Sue Wu
DanyC
addict
Bradykinin is an activates pain receptors. Bradykinin induce ...
www.genscript.com
Mouse Anti cGFP-tag (monoclonal)
The coral green fluorescent protein (cGFP) from vector pRNAT ...
www.genscript.com
ExpressTM ELISA Kit (Mouse)
ELISA
www.genscript.com
Vector-Based siRNA Services
GenScript provides gene synthesis - synthetic gene - for as ...
www.genscript.com