Articles with the keyword: 
Memories may be stored on your DNA
sea-maid submitted, created time 1 month 4 days (www.newscientist.com)
REMEMBER your first kiss? Experiments in mice suggest that patterns of chemical "caps" on our DNA may be responsible for preserving such memories.
To remember a particular event, a specific sequence of neurons must fire at just the right time. For this to happen, neurons must be connected in a certain way by chemical junctions called synapses. But how they last over decades, given that proteins in the brain, including those that form synapses, are destroyed and replaced constantly, is a mystery 
Lifetime lessons of DNA change
sea-maid submitted, created time 6 months 1 week (www.nature.com)
Study of how genome is chemically altered as we age could help us understand disease.
sumsung submitted, created time 1 year 3 months (www.pnas.org)
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that expression profiles of miRNAs are different in lung cancer vs. normal lung, although the significance of this aberrant expression is poorly understood.
jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)
O-6-methylguanine-DNA methyltransferase (MGMT) repairs inappropriately methylated guanine residues in DNA. MGMT promoter methylation and gene silencing are common events in colorectal cancer, and may or may not coexist with the CpG island methylator phenotype (CIMP).
Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors
jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)
Our results demonstrate that DKKs are frequent targets of epigenetic silencing in gastrointestinal tumors, and that loss of DKKs may facilitate tumorigenesis through ß-catenin/TCF independent mechanisms
Molecular studies of major depressive disorder: the epigenetic perspective
penguin submitted, created time 1 year 7 months (www.nature.com)
Major depressive disorder (MDD) is a common and highly heterogeneous psychiatric disorder encompassing a spectrum of symptoms involving deficits to a range of cognitive, psychomotor and emotional processes. As is the norm for aetiological studies into the majority of psychiatric phenotypes, particular focus has fallen on the interplay between genetic and environmental factors. There are, however, several epidemiological, clinical and molecular peculiarities associated with MDD that are hard to explain using traditional gene- and environment-based approaches
Methylation of Lysine 4 on Histone H3: Intricacy of Writing and Reading a Single Epigenetic Mark
Cindy submitted, created time 1 year 8 months (www.sciencedirect.com)
Cells employ elaborate mechanisms to introduce structural and chemical variation into chromatin. Here, we focus on one such element of variation: methylation of lysine 4 in histone H3 (H3K4). We assess a growing body of literature, including treatment of how the mark is established, the patterns of methylation, and the functional consequences of this epigenetic signature
addict submitted, created time 1 year 8 months (www.nature.com)
Regulator of chromatin condensation 1 (RCC1) is the only known guanine nucleotide-exchange factor for the Ran GTPase and has pivotal roles in nucleo-cytoplasmic transport, mitosis, and nuclear-envelope assembly. RCC1 associates dynamically with chromatin through binding to histones H2A and/or H2B in a Ran-regulated manner. Here they found the amino-terminal serine or proline residue of RCC1 is uniquely methylated on its alpha-amino group. Methylation requires removal of the initiating methionine, and the presence of proline and lysine at positions 3 and 4, respectively
athena submitted, created time 1 year 8 months (www.genesdev.org)
"Transcription by RNA polymerase II (polII) is accompanied by dramatic changes in chromatin structure. Numerous enzymatic activities contribute to these changes, including ATP-dependent nucleosome remodeling enzymes and histone modifying enzymes."
Identification of a unique epigenetic sub-microenvironment in prostate cancer
BIOBOSS submitted, created time 1 year 9 months (www3.interscience.wiley.com)
The glutathione S-transferase P1 (GSTP1) gene promoter is methylated in tumour cells in more than 90% of prostate carcinomas. Recently, GSTP1 promoter methylation was identified in tumour-associated stromal cells in addition to the tumour epithelium. Research in National Cancer Institute in USA suggest that stromal cell methylation can occur in a distinct sub-region of prostate cancer and may have implications for understanding tumour biology and clinical intervention.
Gene Methylation in Thyroid Tumorigenesis
athena submitted, created time 1 year 10 months (endo.endojournals.org)
Aberrant gene methylation plays an important role in human tumorigenesis, including thyroid tumorigenesis. Many tumor suppressor genes are aberrantly methylated in thyroid cancer, and some even in benign thyroid tumors, suggesting a role of this epigenetic event in early thyroid tumorigenesis. Methylation of some of these genes tends to occur in certain types of thyroid cancer and is related to specific signaling pathways.
Structural basis in the evolution of plant defense responses
big pig submitted, created time 1 year 10 months (www.plantcell.org)
The results of the study suggest how similar conformations intrinsic to seemingly distinct chemical substrates allowed leguminous plants to use homologous enzymes for two different biosynthetic reactions. The three-dimensional similarity of natural small molecules represents one explanation for how plants may rapidly recruit enzymes for new biosynthetic reactions in response to changing physiological and ecological pressures.
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Protein G, a cell surface protein of group G streptococci, i ...
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Orexin B, rat, mouse
Orexin B is a hypothalamatic neuropeptide stimulating food i ...
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GST Fusion Protein Purification Kit
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SK-BR3
Human breast carcinoma; 250 ug/250 ul.
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