Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae

Reviver submitted, created time 1 year 6 months (www.molecule.org)

"The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-initiating insults such as genotoxic stress. In this report, researchers demonstrate that microRNAs (miRNAs) are important components of the p53 transcriptional network. Global miRNA expression analyses identified a cohort of miRNAs that exhibit p53-dependent upregulation following DNA damage. One such miRNA, miR-34a, is commonly deleted in human cancers and, as shown here, frequently absent in pancreatic cancer cells

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Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

Reviver submitted, created time 1 year 6 months (www.molecule.org)

"p53 is a potent tumor suppressor, whose biological effects are largely due to its function as a transcriptional regulator. Here researchers report that, in addition to regulating the expression of hundreds of protein-coding genes, p53 also modulates the levels of microRNAs (miRNAs). Specifically, p53 can induce expression of microRNA-34a (miR-34a) in cultured cells as well as in irradiated mice, by binding to a perfect p53 binding site located within the gene that gives rise to miR-34a. Processing of the primary transcript into mature miR-34a involves the excision of a 30 kb intron

Submit comment | Blog It | Email It | Keywords: transcriptional regulator p53 miR-34a p53-dependent apoptosis