Articles with the keyword: 
Biological principles of microRNA-mediated regulation: shared themes amid diversity
sea-maid submitted, created time 2 months 2 weeks (www.nature.com)
Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic development and physiology. Amidst an extensive regulatory web that is predicted to involve thousands of transcripts, emergent themes are now beginning to illustrate how microRNAs have been incorporated into diverse settings. These include potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulation of target batteries, and the reversibility of some aspects of microRNA-mediated repression 
sea-maid submitted, created time 2 months 2 weeks (www.sciencedirect.com)
Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16Ink4a. We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural stem cells but that expression declines with age. This decrease is partly caused by the increasing expression of let-7b microRNA, which is known to target HMGA2
No place to hide for herpes virus
sea-maid submitted, created time 6 months 4 days (www.newscientist.com)
They say the difference between herpes and love is that herpes lasts forever. But new research hints at a way to chase the cold sore virus from its hiding place and get rid of it for good.
jerry submitted, created time 7 months 2 weeks (www.immunity.com)
MicroRNAs (miRNAs) appear to be linked to the regulation of a multitude of genes.
This research shows what happens when the regulatory control by miRNA-155 is removed from one of its specific targets, the deaminase AID. Preview by Desiderio.
MicroRNA Sets Stage for Human Therapies
sumsung submitted, created time 9 months 1 week (sciencenow.sciencemag.org)
Scientists have taken a big step toward developing therapies based on naturally occurring tiny RNA molecules called microRNAs. In the first successful experiment with primates, researchers have blocked microRNAs to lower cholesterol levels in monkeys. This achievement builds hope that the strategy could one day be used to attack human diseases. Safety concerns still linger, however.
Triumphs and tribulations for RNA interference
jane2007 submitted, created time 9 months 1 week (www.nature.com)
Two studies highlight promise and problems for gene silencing technique. Researchers could offer a new way by microRNA interference to treat conditions from cancer to cardiovascular disease. But another study shows that the effects of RNAi on genes involved in a severe form of blindness called age-related macular degeneration (AMD). In this case RNAi-causing drugs have already gone into trials. It isn't that the drugs don't work; it's that they work no matter what siRNA sequence is used. This brings the current understanding of the mechanism of RNA interference into question.
"Junk" RNA may play a role in vertebrate evolution
sumsung submitted, created time 10 months 3 weeks (www.sciam.com)
Genetic material once dismissed as mere "junk" may in fact be responsible to the evolution of simple invertebrates into more complex organisms sporting backbones, according to a new study.
MicroRNAs Keep Tumors in Place
Eric wu submitted, created time 11 months 4 weeks (sciencenow.sciencemag.org)
When a cancer spreads, or metastasizes, it often becomes incurable. Now scientists are eying a new factor that may prompt tumor cells to start roaming: a deficit of molecules known as microRNAs, which modulate gene expression. Building on earlier work linking microRNAs to cancer, researchers have found that a lack of certain microRNAs encourages tumors to spread. They also report that in mice, the microRNAs can be manipulated to slow metastasis.
I am very glad that this news has opened a path toward explaining the follow article 'Breast-Cancer Genes May Come With Lower Risk'
MicroRNA: A New Player in Breast Cancer Development
MedUnion submitted, created time 1 year 1 month (www.mupnet.com)
Breast cancer is the leading cause of death in women in North America. The etiology of breast cancer is complex, and genetic background and environmental factors are believed to contribute to the complexities. Over the past decades, a large body of literature has demonstrated that gene expression profile may be a useful tool to define the signature of cancer and predict the prognosis or response to treatment. Recently, microRNA (miRNA) expression profile calls a great attention to define various types of cancers
sumsung submitted, created time 1 year 3 months (www.pnas.org)
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that expression profiles of miRNAs are different in lung cancer vs. normal lung, although the significance of this aberrant expression is poorly understood.
Small molecules may explain psoriasis
bianjie submitted, created time 1 year 5 months (www.eurekalert.org)
A research team at the Swedish medical university Karolinska Institutet has shown for the time that microRNA, small RNA molecules, may play an important role in the development of inflammatory skin diseases such as psoriasis and atopic eczema. The research team is led by Professor Mona Stle, one of Sweden's most prominent scientists in the field.
Reviver submitted, created time 1 year 6 months (www.molecularpain.com)
"Active regulation of gene expression in the nervous system plays an important role in the development and/or maintenance of inflammatory pain. MicroRNA (miRNA) negatively regulates gene expression via posttranscriptional or transcriptional inhibition of specific genes. To explore the possible involvement of miRNA in gene regulation during inflammatory pain, they injected complete Freund adjuvant (CFA) unilaterally into the rat masseter muscle and quantified changes in neuron-specific mature miRNAs in the trigeminal ganglion (TG)
Possible target found for boosting microRNA action
daphne submitted, created time 1 year 7 months (www.nature.com)
Study shows how micro molecules interfere with gene expression. Tiny fragments of RNA called microRNAs are known to interfere with gene expression, but how? A new study hints that they get involved right at the start of the game — they seem to prevent protein production before it even starts.
Minuscule Molecules Pack A Powerful Punch In Immune Defence
collapsar submitted, created time 1 year 8 months (www.medicalnewstoday.com)
Scientists have shown that a tiny microRNA molecule called miR-155, plays a critical role in immune defence and may be a lynchpin in the immune system. The findings reported today in Science reveal that mice lacking the bic/miR-155 gene, one of the world's first microRNA 'knockout' mice, have compromised immune systems and are less able to resist infection and mount an immune response to bacteria like Salmonella typhimurium, a leading cause of human gastroenteritis. They also develop symptoms similar to those of human autoimmune disorders.
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
Cindy submitted, created time 1 year 8 months (www.sciencemag.org)
The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of {alpha}–myosin heavy chain ({alpha}MHC) and up-regulation of ßMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the {alpha}MHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of ßMHC in response to stress and hypothyroidism
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