Molecular Pathway May Predict Chemotherapy Effectiveness

june submitted, created time 1 year 4 months (www.medicalnewstoday.com)

A common molecular pathway could help physicians predict which lung cancer patients will benefit from chemotherapy drugs, according to new research from a multidisciplinary team at the University of Cincinnati (UC).

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Single Nucleotide Polymorphisms at the TP53-Binding or Responsive Promoter Regions of BAX and BCL2 Genes and Risk of Squamous Cell Carcinoma of the Head and Neck

jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)

Our data suggest that the risk of SCCHN may be associated with these two SNPs of BAX and BCL2 promoter regions in SCCHN, particularly among TP53 heterozygotes. Larger studies are needed to validate these findings.

Submit comment | Blog It | Email It | Keywords: Case-control study Apoptosis Genetic susceptibility Molecular epidemiology Polymorphism

Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn and arsenic related skin lesions

addict submitted, created time 1 year 8 months (carcin.oxfordjournals.org)

Single nucleotide polymorphisms in genes related to DNA repair capacity and UV exposure have not been well investigated in relation to skin lesions associated with arsenic exposure. This population based case-control study, of 600 cases and 600 controls, frequency matched on age and gender in Pabna, Bangladesh in 2001-2002, investigated the association and potential effect modification between polymorphisms in XPD (Lys751Gln and Asp312Asn) genes, tendency to sunburn and arsenic related skin lesions

Submit comment | Blog It | Email It | Keywords: Arsenic DNA repair hyperkeratosis melanosis ERCC2 molecular epidemiology environmental health