What would be happen for losing of -tubulin polyglutamylation in ROSA22 mice ?

angelfish submitted, created time 1 year 10 months (www.pnas.org)

“Microtubules function as molecular tracks along which motor proteins transport a variety of cargo to discrete destinations within the cell. The carboxyl termini of - and -tubulin can undergo different posttranslational modifications, including polyglutamylation, which is particularly abundant within the mammalian nervous system. Thus, this modification could serve as a molecular "traffic sign" for motor proteins in neuronal cells

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A demon of a device - Light makes molecular machines perform trick.