In silico gene expression analysis

annatto submitted, created time 1 year 4 months (www.molecular-cancer.com)

"The overriding goal of this review is to present the scientific community with a critical overview of these strategies, so that they can be effectively added to the tool box of biomedical researchers focused on identifying the molecular mechanisms of disease."

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Molecular mechanisms of memory reconsolidation

psychologist submitted, created time 1 year 9 months (www.nature.com)

Memory reconsolidation has been argued to be a distinct process that serves to maintain, strengthen or modify memories. Specifically, the retrieval of a previously consolidated memory has been hypothesized to induce an additional activity-dependent labile period during which the memory can be modified. Understanding the molecular mechanisms of reconsolidation could provide crucial insights into the dynamic aspects of normal mnemonic function and psychiatric disorders that are characterized by exceptionally strong and salient emotional memories.

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Neuronal polarity: from extracellular signals to intracellular mechanisms

athena submitted, created time 1 year 9 months (www.nature.com)

How do neurons develop their morphologically and molecularly distinct compartments?

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New discover of structures of the Cd44–hyaluronan complex

nomad submitted, created time 1 year 10 months (www.nature.com)

Regulation of transient interactions between cells and the ubiquitous matrix glycosaminoglycan hyaluronan is crucial to such fundamental processes as embryonic development and leukocyte homing. Cd44, the primary cell surface receptor for hyaluronan, binds ligand via a lectin-like fold termed the Link module, but only after appropriate functional activation. The molecular details of the Cd44-hyaluronan interaction and hence the structural basis for this activation are unknown. Here we present the first crystal structure of Cd44 complexed with hyaluronan

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Cyclin D1 expression in mesenchymal cells

crackpot submitted, created time 1 year 10 months (www.jcb.org)

"High molecular weight (HMW) hyaluronan (HA) is widely distributed in the extracellular matrix, but its biological activities remain incompletely understood. We previously reported that HMW-HA binding to CD44 antagonizes mitogen-induced S-phase entry in vascular smooth muscle cells (SMCs; Cuff, C.A., D. Kothapalli, I. Azonobi, S. Chun, Y. Zhang, R. Belkin, C. Yeh, A. Secreto, R.K. Assoian, D.J. Rader, and E. Puré. 2001. J. Clin. Invest. 108:1031–1040); we now characterize the underlying molecular mechanism and document its relevance in vivo

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Obesity-Related Derangements in Metabolic Regulation

biscuits submitted, created time 1 year 11 months (arjournals.annualreviews.org)

Lifestyle habits that encourage overconsumption of energy-rich foods while also discouraging regular physical activity has leaded to alarming trend of the incidence of obesity. These environmental influences create a chronic energy imbalance that leads to persistent weight gain in the form of body fat and a host of other abnormalities in metabolic homeostasis. As adiposity increases, so does the risk of developing comorbidities such as diabetes, hypertension, and cardiovascular disease

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