What would be happen for losing of -tubulin polyglutamylation in ROSA22 mice ?

angelfish submitted, created time 1 year 10 months (www.pnas.org)

“Microtubules function as molecular tracks along which motor proteins transport a variety of cargo to discrete destinations within the cell. The carboxyl termini of - and -tubulin can undergo different posttranslational modifications, including polyglutamylation, which is particularly abundant within the mammalian nervous system. Thus, this modification could serve as a molecular "traffic sign" for motor proteins in neuronal cells

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A switch of bistable gene expression is found

big pig submitted, created time 1 year 10 months (www.nature.com)

A new study examines the agn43 epigenetic switch of Escherichia coli, providing an alternative to feedback regulation as a model for gene expression regulation. Through a combination of synthetic network construction and computational modeling, the researchers show that the generated bistable gene expression involves transitions between several rarely occupied states between 'on' and 'off'.

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