Molecular basis for passive immunotherapy of Alzheimer's disease

benjiamin submitted, created time 1 year 3 months (www.pnas.org)

Amyloid aggregates of the amyloid-β(Aβ) peptide are implicated in the pathology of Alzheimer's disease. Anti-Aβ monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.

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Possible Hepatitis C vaccine

sumsung submitted, created time 1 year 4 months (www.eurekalert.org)

Hepatitis C virus infects up to 500,000 people in the UK alone, many of the infections going undiagnosed. It is the single biggest cause of people requiring a liver transplant in Britain. Now scientists have found monoclonal antibodies which may make a successful vaccine a reality, researchers heard today, Sept. 4, 2007, at the Society for General Microbiology's 161st Meeting at the University of Edinburgh, UK, which runs Sept. 3-6, 2007.

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Antibody retards liver cancer cell growth

bianjie submitted, created time 1 year 5 months (www.sciencedaily.com)

U.S. oncologists have used a new monoclonal antibody to achieve significant reductions in liver cancer tumor growth in both human and mouse models.

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Antibody retards growth and induces death in liver cancer cells

bianjie submitted, created time 1 year 5 months (www.eurekalert.org)

Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer. Using a newly available monoclonal antibody, they demonstrated dramatic reductions in tumor cell proliferation and survival in human and mouse hepatocellular cancer cell lines. This finding has significant implications not only for the treatment of liver cancer but for a number of different types of cancer.

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Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1

dovechocolate submitted, created time 1 year 7 months (www.pnas.org)

CD30 is a member of the TNF receptor superfamily. Overexpression of CD30 on some neoplasms versus limited expression on normal tissues makes this receptor a promising target for antibody-based therapy. Radioimmunotherapy of cancer with radiolabeled antibodies has shown promise. In this study, we evaluated the therapeutic efficacy of an anti-CD30 antibody, HeFi-1, armed with 211At in a leukemia (karpas299) model and with 90Y in a lymphoma (SUDHL-1) model. Furthermore, we investigated the combination therapy of 211At-HeFi-1 with unmodified HeFi-1 in the leukemia model.

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The insulin and EGF receptor structures: new insights into ligand-induced receptor activation

athena submitted, created time 1 year 9 months (www.sciencedirect.com)

"The insulin receptor (IR) and epidermal growth factor receptor (EGFR; also known as ErbB) families exhibit similarities in the composition of their ectodomains. The past five years have seen structures determined for all members of the EGFR family including some complexes with ligand or monoclonal antibody fragments. These structures have led to a clearer understanding of their mechanism of activation and inhibition."

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Patients With Chronic Pancreatitis Have Islet Progenitor Cells in Their Ducts, but Reversal of Overt Diabetes in NOD Mice by Anti-CD3 Shows No Evidence for Islet Regeneration

alpha submitted, created time 1 year 9 months (diabetes.diabetesjournals.org)

"Monoclonal antibodies to T-cell coreceptors have been shown to tolerise autoreactive T-cells and prevent or even reverse autoimmune pathology."

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