Mitochondrial Mutations Make Tumors Spread

jane2007 submitted, created time 7 months 3 weeks (sciencenow.sciencemag.org)

Why is it that cancer often strikes its final, fatal blow when a tumor spreads to other organs? It's because of the metastasis of mitochondrial DNA mutations.

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Cancer as a “Mitochondriopathy”

MedUnion submitted, created time 1 year 5 months (www.mupnet.com)

Mitochondria are subcellular organelles, whose well-known function is to produce ATP through the oxidative phosphorylation system. Alterations in respiratory activity and mitochondrial DNA (mtDNA) appear to be a general feature of malignant cells. The presence of mtDNA mutations has been reported in various cancer cells, and the abundance of mtDNA damage is consistent with the intrinsic susceptibility to constitutive oxidative stress

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