American association of physical anthropologists meeting-Tuberculosis Jumped from Humans to Cows, Not Vice Versa

sea-maid submitted, created time 6 months 3 weeks (www.sciencemag.org)

This is about an American association of physicial anthropologists meeting,which
mainly talk about the thesis "Tuberculosis Jumped From Humans to Cows, Not Vice Versa."

At the meeting, a DNA study of 10 species of mycobacteria showed that early humans were infected with strains of Mycobacterium tuberculosis, which cause TB, long before they began herding cattle. That suggests that it was humans who transmitted the disease to bovids and other animals

3 comments | Blog It | Email It | Keywords: mycobacteria evolutionary biology domestic animals animals Pfiser origins of tuberculosis origins of disease cows Tuberculosis

Calcineurin activation spares invading Mycobacterium from death

addict submitted, created time 1 year 4 months (www.cell.com)

Pathogenic mycobacteria survive within macrophages by avoiding lysosomal delivery, instead residing in mycobacterial phagosomes. Upon infection, the leukocyte-specific protein coronin 1 is actively recruited to mycobacterial phagosomes, where it blocks lysosomal delivery by an unknown mechanism. Analysis of macrophages from coronin 1-deficient mice showed that coronin 1 is dispensable for F-actin-dependent processes such as phagocytosis, motility, and membrane ruffling

Submit comment | Blog It | Email It | Keywords: Mycobacteria Calcineurin