Krox20–Nab2 Interactions in Myelination

kavin submitted, created time 7 months 23 hours (www.jneurosci.org)

To study the mechanisms underlying myelination, Desmazieres et al. produced transgenic mice that express a mutant form of Krox20 that causes congenital hypomyelinating neuropathy in humans: a mutation that causes a single amino acid substitution, which disrupts interaction between Krox20 and its cofactor Nab2. Interactions between Krox20 and Nab2 appear essential for Krox20 function in peripheral myelination, but not in hindbrain patterning.

2 comments | Blog It | Email It | Keywords: congenital hypomyelinating neuropathy neuropathy cofactors multiple sclerosis myelin alzhymer's transgenic mice myelination Krox20–Nab2

Brain Stem Cells Reverse Myelin Deficiency in Mice

sea-maid submitted, created time 7 months 1 day (www.washingtonpost.com)

"The fact that they were able to get at least some of these animals to survive, and show that physiologically and behaviorally they are doing well, is an advance," said James Goldman.

Myelin is a structure, comprised of protein and fat, that envelops long neuronal fibers called axons. In this study, Researchers report they have used neural stem cells to correct a congenital brain disorder in mice. And this is a very important advance.

1 comment | Blog It | Email It | Keywords: glial progenitor cells multiple schlerosis myelination shiverer mice adrenoleukodystrophy Myelin