Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

william submitted, created time 1 year 2 months (www.pnas.org)

Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix–loop–helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over the program of smooth muscle cell (SMC) differentiation.

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Inactivation of Myocardin and p16 and a Differentiation Defect during Malignant Transformation

cappuccion submitted, created time 1 year 9 months (www.sciencedirect.com)

Myocardin is known as an important transcriptional regulator in smooth and cardiac muscle development. It is frequently repressed during human malignant transformation, contributing to a differentiation defect. In this research, the scientists demonstrated that myocardin is a transcriptional target of TGFβ required for TGFβ-mediated differentiation of human fibroblasts. Serum deprivation, intact contact inhibition response, and the p16ink4a/Rb pathway contribute to myocardin induction and differentiation

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