MYPT1 regulates mitosis by antagonizing Plk1

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation

alpha submitted, created time 1 year 9 months (www.jcb.org)

"Antigen (Ag) capture and presentation onto major histocompatibility complex (MHC) class II molecules by B lymphocytes is mediated by their surface Ag receptor (B cell receptor [BCR]). Therefore, the transport of vesicles that carry MHC class II and BCR–Ag complexes must be coordinated for them to converge for processing. In this study, we identify the actin-associated motor protein myosin II as being essential for this process. Myosin II is activated upon BCR engagement and associates with MHC class II–invariant chain complexes

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