Insulin and Epidermal Growth Factor’s Activation of Extracellular-Signal Regulated Kinases 1/2 and DNA Synthesis Is Inhibited by Four Cardiac Hormones

Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function

amanda submitted, created time 1 year 7 months (eurheartj.oxfordjournals.org)

"We demonstrate for the first time that CgA is produced by human myocardium and exerts negative inotropic and lusitropic effects on mammalian heart. CgA may represent a key player in neuroendocrine regulation of cardiac function and a potential therapeutic target in heart failure. "

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Corin I555(P568) Allele Is Associated With Enhanced Cardiac Hypertrophic Response to Increased Systemic Afterload

julie submitted, created time 1 year 8 months (hyper.ahajournals.org)

"Corin activates pro–A-type naturetic peptide and pro–B-type naturetic peptide into biologically active molecules."

Submit comment | Blog It | Email It | Keywords: hypertension left ventricular hypertrophy natriuretic peptides genetic polymorphisms left ventricular remodeling