Articles with the keyword: 
Nuclear Pore Composition Regulates Neural Stem/Progenitor Cell Differentiation in the Mouse Embryos
jerry submitted, created time 4 months 3 weeks (www.developmentalcell.com)
Serving as the primary conduit for communication between the nucleus and the cytoplasm, nuclear pore complexes (NPCs) impact nearly every cellular process. The extent to which NPC composition varies and the functional significance of such variation in mammalian development has not been investigated. Here they report that a null allele of mouse nucleoporin Nup133, a structural subunit of the NPC, disrupts neural differentiation. They found that expression of Nup133 was cell type and developmental stage restricted, with prominent expression in dividing progenitors 
Nerve stem cells coaxed into working nerve cells
Darkfrog submitted, created time 5 months 2 weeks (www.medicalnewstoday.com)
Researchers at the UT Southwestern Medical Center have found a number of small compounds that stimulate nerve stem cells to develop into nerve cells. They synthesized a version that they are calling isoxazole-9, or ISX-9. This compound seems to have applications in nerve damage and brain cancer chemotheryapy.
Study Shows Novel Way to Trigger New Neuron Production in the Aging Brain
akshetty2007 submitted, created time 1 year 3 months (www.dukehealth.org)
DURHAM, N.C. -- Researchers have shown for the first time that putting two specific types of neural cells directly into an aging brain can kick-start creation of brain cells linked to learning and memory.
It has been shown over the last decade that brain cells replicate, a finding that had run counter to previously accepted dogma. The area where neuron-forming stem cells perform much of this replication is the hippocampus, part of the brain linked to memory and learning, and an area affected in older people as well as those with Alzheimer's disease
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate
Reviver submitted, created time 1 year 4 months (www.jcb.org)
"The Retinoblastoma protein p107 regulates the neural precursor pool in both the developing and adult brain. As p107-deficient mice exhibit enhanced levels of Hes1, we questioned whether p107 regulates neural precursor self-renewal through the repression of Hes1. p107 represses transcription at the Hes1 promoter. Despite an expanded neural precursor population, p107-null mice exhibit a striking reduction in the number of cortical neurons. Hes1 deficiency rescues neurosphere numbers in p107-null embryos
Regeneration of neural crest derivatives in the Xenopus tadpole tail
annatto submitted, created time 1 year 6 months (www.biomedcentral.com)
"After amputation of the Xenopus tadpole tail, a functionally competent new tail is regenerated. It contains spinal cord, notochord and muscle, each of which has previously been shown to derive from the corresponding tissue in the stump. The regeneration of the neural crest derivatives has not previously been examined and is described in this paper.On regeneration there is no induction of a new neural crest similar to that seen in embryonic development. However there is some regeneration of neural crest derivatives
Neural stem cells may solve embryonic cell issue
angelfish submitted, created time 1 year 6 months (www.hypography.com)
The discovery -- reported recently in Developmental Dynamics, a journal of the American Association of Anatomists published by John Wiley & Sons, Inc. -- may in many instances provide a non-controversial substitute for embryonic stem cells. Embryonic stem cells are unique, because they can differentiate into any cell type of the body. Their use, however, raises ethical concerns because embryos are being destroyed in the process.
julie submitted, created time 1 year 6 months (brain.oxfordjournals.org)
"Human embryonic stem cells (hESCs) are a potential source of defined tissue for cell-based therapies in regenerative neurology. In order for this potential to be realized, there is a need for the evaluation of the behaviour of human embryonic stem cell-derived neural stem cells (hES-NSCs) both in the normal and the injured CNS. Using normal tissue and two experimental models, we examined the response of clinically compatible hES-NSCs to physiological and pathological signals
Neural stem cells under chemical control
red monkey submitted, created time 1 year 6 months (www.nature.com)
"The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the proliferation and self-renewal of NSCs, which we refer to as the 'ground state', remains largely uncharacterized. Although the candidate gene approach has uncovered vital pathways in NSC biology, so far only a few highly studied pathways have been investigated
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