Gene Identified for Deadly Childhood Cancer

sea-maid submitted, created time 3 months 5 days (sciencenow.sciencemag.org)

Fifteen years of genetic sleuthing have finally paid off: Researchers have nailed the gene that appears to cause an inherited form of neuroblastoma, a cancer of the nervous system that predominantly strikes children. Scientists are optimistic that the findings will allow them to develop disease screening for some families, as well as lead to potential new therapies.

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Positron emission tomography (PET) imaging of neuroblastoma and melanoma with 64Cu-SarAr immunoconjugates

franklin submitted, created time 1 year 1 month (www.pnas.org)

The advancement of positron emission tomography (PET) depends on the development of new radiotracers that will complement 18F-FDG. Copper-64 (64Cu) is a promising PET radionuclide, particularly for antibody-targeted imaging, but the high in vivo lability of conventional chelates has limited its clinical application.

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Neuroblastoma Expert Reviews Progress And Challenges In Fighting Difficult Pediatric Cancer

cappuccion submitted, created time 1 year 5 months (www.sciencedaily.com)

Childhood cancers are fortunately rare, but among them, neuroblastoma is a special case, accounting for 7 percent of all childhood cancers, but 15 percent of childhood cancer deaths. It typically occurs as a solid tumor in the abdomen, but also in the neck, chest, and pelvis, developing in the network of the body's sympathetic nervous system.

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Researchers Use Poliovirus to Destroy Neuroblastoma Tumors in Mice

BIOBOSS submitted, created time 1 year 8 months (www.eurekalert.org)

The cause of one notorious childhood disease, poliovirus, could be used to treat the ongoing threat of another childhood disease, neuroblastoma. In the March 15 issue of Cancer Research, researchers from Stony Brook University report that an attenuated -- or non-virulent -- form of poliovirus is effective in obliterating neuroblastoma tumors in mice, even when the mice had been previously vaccinated against the virus.

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