Krox20–Nab2 Interactions in Myelination

kavin submitted, created time 7 months 23 hours (www.jneurosci.org)

To study the mechanisms underlying myelination, Desmazieres et al. produced transgenic mice that express a mutant form of Krox20 that causes congenital hypomyelinating neuropathy in humans: a mutation that causes a single amino acid substitution, which disrupts interaction between Krox20 and its cofactor Nab2. Interactions between Krox20 and Nab2 appear essential for Krox20 function in peripheral myelination, but not in hindbrain patterning.

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