Mutual regulation of c-Jun and ATF2 by transcriptional activation and subcellular localization

changdeng submitted, created time 1 year 6 months (www.pubmedcentral.nih.gov)

This article uses an improved BiFC system and demonstrates that ATF2 is a nucleocytoplasmic shuttling protein. Its nuclear export is inhibited by the heterodimerization with its partner c-Jun and its nuclear import is inhibited by ATF2 homodimerization. Importantly, nuclear localization of ATF2 is tightly regulated by physiological stimuli involved in cell differentiation and cell death

Submit comment | Blog It | Email It | Keywords: BiFC nuclear import nuclear protein localization nuclear localization sequence subcellular localization

Pax Transactivation-Domain Interacting Protein Is Required for Urine Concentration and Osmotolerance in Collecting Duct Epithelia

alpha submitted, created time 1 year 8 months (jasn.asnjournals.org)

"Pax transactivation-domain interacting protein (PTIP) is a widely expressed nuclear protein that is essential for early embryonic development."

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Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1/GCNF)

crackpot submitted, created time 1 year 9 months (www.genome.org)

"The number of vertebrae in pigs varies and is associated with meat productivity. Wild boars, which are ancestors of domestic pigs, have 19 vertebrae. In comparison, European commercial breeds have 21–23 vertebrae, probably owing to selective breeding for enlargement of body size. Researchers previously identified two quantitative trait loci (QTL) for the number of vertebrae on Sus scrofa chromosomes (SSC) 1 and 7. These QTL explained an increase of more than two vertebrae. Here, they performed a map-based study to define the QTL region on SSC1

Submit comment | Blog It | Email It | Keywords: Animal Sciences NR6A1&GCNF nuclear protein nuclear receptor

Molecular mechanism of the nuclear protein import cycle

amanda submitted, created time 1 year 9 months (www.nature.com)

The nuclear import of proteins through nuclear pore complexes (NPCs) illustrates how a complex biological function can be generated by a spatially and temporally organized cycle of interactions between cargoes, carriers and the Ran GTPase. Recent work has given considerable insight into this process, especially about how interactions are coordinated and the basis for the molecular recognition that underlies the process.

Submit comment | Blog It | Email It | Keywords: nuclear DNA nuclear permeability molecular interactions nuclear protein