Physical plasticity of the nucleus in stem cell differentiation

zibba submitted, created time 1 year 3 months (www.pnas.org)

Cell differentiation in embryogenesis involves extensive changes in gene expression structural reorganization within the nucleus, including chromatin condensation and nucleoprotein immobilization. We hypothesized that nuclei in naive stem cells would therefore prove to be physically plastic and also more pliable than nuclei in differentiated cells.

Submit comment | Blog It | Email It | Keywords: cell differentiation chromatin condensation nucleoprotein immobilization