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12

Researchers Find Good Fat in Human Adults

piggy submitted, created time 11 months 1 week (sciencenow.sciencemag.org)

Fat that keeps you lean sounds like a contradiction in terms, but that's what brown fat does. Okay, so primarily it keeps you warm, but it does so by burning energy. Three new studies reveal that, contrary to long-standing assumptions that brown fat was active only in easily chilled infants, this energy-using form of fat remains functional in adults. The results bolster researchers' hopes of exploiting brown fat to control weight.

9

New Fat-fighting Pathway Discovered

piggy submitted, created time 11 months 2 weeks (www.sciencedaily.com)

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a process that controls the amount of fat that cells store for use as a back-up energy source. Disruption of this process allows cellular fat to accumulate—a key factor in age-related metabolic diseases such as obesity and type 2 obesity

12

Influence of obesity gene can be offset by healthy diet

piggy submitted, created time 1 year 2 weeks (www.eurekalert.org)

Children who carry a gene strongly associated with obesity could offset its effect by eating a low-energy-density diet, according to new research from UCL (University College London) and the University of Bristol published today in PLoS ONE.

The study, based on data from a sample of 2275 children from the Bristol-based ALSPAC study (Children of the 90s) provides evidence that people might be able to avoid becoming obese if they adopt a healthier diet with a low energy density – even those who carry the FTO gene, identified as being a high risk gene for obesity

12

Obesity Gene Involved in Weight Gain Response to High-Fat Diet Identified

piggy submitted, created time 1 year 3 weeks (www.sciencedaily.com)

Scientists have determined that a specific gene plays a role in the weight-gain response to a high-fat diet.

The finding in an animal study suggests that blocking this gene could one day be a therapeutic strategy to reduce diet-related obesity and associated disorders, such as diabetes and liver damage, in humans.

The researchers found that a diet rich in fat induced production of this gene, called protein kinase C beta (PKC beta), in the fat cells of mice. These mice rapidly gained weight while eating a high-fat diet for twelve weeks.

8

Natural Brain Substance Blocks Weight Gain in Mice, Researchers Discover

piggy submitted, created time 1 year 1 month (www.sciencedaily.com)

Mice with increased levels of a natural brain chemical don't gain weight when fed a high-fat diet, researchers at UT Southwestern Medical Center have found.

The chemical, orexin, works by increasing the body's sensitivity to the "weight-loss hormone," leptin, the researchers report.

Finding a way to boost the orexin system may prove useful as a therapy against obesity, said Dr. Masashi Yanagisawa, professor of molecular genetics at UT Southwestern and senior author of the study, which appears in the January issue of Cell Metabolism.

11

Microbe Composition In Gut May Hold Key To One Cause Of Obesity

piggy submitted, created time 1 year 2 months (www.sciencedaily.com)

Biodesign Institute in collaboration with colleagues atthe Mayo Clinic, Arizona, and the University of Arizona, reveal atantalizing link between differing microbial populations in the humangut and body weight among three distinct groups: normal weightindividuals, those who have undergone gastric bypass surgery, andpatients suffering the condition of morbid obesity—a serious, oftenlife-threatening condition associated with diabetes, cardiovasculardisease, cancer and psychosocial disorders. Obesity affects around 4million Americans and, each year, some 300,000 die from obesity-relatedillness

9

On a High-Fat Diet, Protective Gene Variant Becomes Bad Actor

sea-maid submitted, created time 1 year 2 months (www.sciencedaily.com)

New evidence in mice bolsters the notion that a version of a gene earlier shown to protect lean people against weight gain and insulin resistance can have the opposite effect in those who eat a high-fat diet and are heavier, reveals a report in the January 7th issue of the journal Cell Metabolism, a Cell Press publication

8

Single gene fuels overeating risk

sea-maid submitted, created time 1 year 2 months (news.bbc.co.uk)

Scientists have produced more evidence that carrying the wrong variant of a single gene can raise the risk of overeating and obesity.

12

Disabling enzyme allows mice to gorge without becoming obese, new study finds

piggy submitted, created time 1 year 2 months (www.eurekalert.org)

Researchers at the University of California, Berkeley, have identified a new enzyme that plays a far more important role than expected in controlling the breakdown of fat. In a new study to be published Jan. 11 in the journal Nature Medicine, researchers report that mice that have had this enzyme disabled remained lean despite eating a high-fat diet and losing a hormone that suppresses appetite

9

Obesity Starts in the Head? Six Newly Discovered Genes for Obesity Have a Neural Effect

piggy submitted, created time 1 year 2 months (www.sciencedaily.com)

Obesity is known to increase the risk of chronic disorders, such as diabetes (type 2). An international team of scientists with German participation through the Helmholtz Zentrum München identified six new obesity genes. Gene expression analyses have shown that all six genes are active in brain cells.

The international GIANT (Genetic Investigation of Anthropometric Parameters) consortium works on the discovery of obesity genes. So far, the scientists have analyzed two million DNA variations in fifteen genome-wide association studies with a total of more than 32,000 participants

12

Control of blood vessels a possible weapon against obesity

piggy submitted, created time 1 year 2 months (www.eurekalert.org)

Mice exposed to low temperatures develop more blood vessels in their adipose tissue and metabolize body fat more quickly, according to a new study from Karolinska Institutet. Scientists now hope to learn how to control blood vessel development in humans in order to combat obesity and diabetes.

The growth of fat cells and their metabolism depend on oxygen and blood-borne nutrients. A possible way to regulate the amount of body fat – in order, for instance, to combat obesity – can therefore be to affect the development of blood vessels in the adipose tissue

10

Study raises hope for obesity treatment

sea-maid submitted, created time 1 year 2 months (news.yahoo.com)

U.S. researchers may have found an obesity treatment that unlocks the fat-fighting promise of leptin, an appetite-suppressing hormone once hailed as the answer to the battle of the bulge.

11

Weight loss surgery improves sexual function in men

sea-maid submitted, created time 1 year 2 months (news.yahoo.com)

Sexual dysfunction that commonly occurs in morbidly obese men improves after weight loss surgery, according to a new study.

7

Obesity Surgery Reverses Diabetes in Teens

sea-maid submitted, created time 1 year 2 months (www.time.com)

Obesity surgery can reverse diabetes in teens, just as it does in adults, according to a small study

10

Surgeon uses human fat to run his cars

sea-maid submitted, created time 1 year 2 months (www.independent.co.uk)

A leading Beverly Hills plastic surgeon claims to have found an environmentally friendly way to combine two of America's great obsessions – after converting his 4x4 to run on fat removed from clients during liposuction operations.

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