Lifelong Effects of Childhood Obesity

jane2007 submitted, created time 1 year 1 month (www.time.com)

Doctor, firefighter, astronaut. These are the things kids want to be when they grow up. Obese 35-year-old with type 2 diabetes and coronary heart disease? Not exactly. But according to two studies published this week in the New England Journal of Medicine (NEJM), that's where our children are headed, unless monumental — and immediate — changes are made in the effort to curb childhood obesity.

Submit comment | Blog It | Email It | Keywords: childhood obesity coronary heart disease obesity-related diabetes type 2 diabetes (T2D) heart disease

Leisure time physical activity in middle age predicts the metabolic syndrome in old age: results of a 28-year follow-up of men in the Oslo study

saury submitted, created time 1 year 5 months (www.biomedcentral.com)

“Physical activity during leisure recorded in middle age prior to the current waves of obesity and diabetes had an independent predictive association with the presence of the metabolic syndrome but not significantly so with diabetes 28 years later in life, when the subjects were elderly.”

Submit comment | Blog It | Email It | Keywords: diabetes obesity-related diabetes

Prediction of Incident Diabetes Mellitus in Middle-aged Adults

angelfish submitted, created time 1 year 7 months (archinte.ama-assn.org)

"Parental diabetes, obesity, and metabolic syndrome traits effectively predict T2DM risk in a middle-aged white population sample and were used to develop a simple T2DM prediction algorithm to estimate risk of new T2DM during a 7-year follow-up interval."

Submit comment | Blog It | Email It | Keywords: T2DM type 2 diabetes obesity obesity-related diabetes

Loss of Stearoyl-CoA Desaturase-1 Improves Insulin Sensitivity in Lean Mice but Worsens Diabetes in Leptin-Deficient Obese Mice

amanda submitted, created time 1 year 7 months (diabetes.diabetesjournals.org)

"The lipogenic gene stearoyl-CoA desaturase (SCD)1 appears to be a promising new target for obesity-related diabetes, as mice deficient in this enzyme are resistant to diet- and leptin deficiency–induced obesity. The BTBR mouse strain replicates many features of insulin resistance found in humans with excess visceral adiposity."

Submit comment | Blog It | Email It | Keywords: insulin obesity-related diabetes visceral adiposity adipose tissue